SPARC and COL13A1

Data Source:
HPRD (in vitro)

		SPARC	COL13A1
Description		secreted protein acidic and cysteine rich	collagen type XIII alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Cytoplasm Mitochondrion Plasma Membrane Cell Surface Nuclear Matrix Platelet Alpha Granule Platelet Alpha Granule Membrane Platelet Alpha Granule Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Endocytic Vesicle Lumen Glutamatergic Synapse	Extracellular Region Collagen Trimer Collagen Type XIII Trimer Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell-cell Junction Extracellular Matrix Postsynaptic Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Extracellular Matrix Binding	Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Ossification Negative Regulation Of Endothelial Cell Proliferation Platelet Degranulation Receptor-mediated Endocytosis Heart Development Response To Gravity Response To Lead Ion Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Cell Morphogenesis Extracellular Matrix Organization Lung Development Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Cytokine Wound Healing Response To Peptide Hormone Response To Ethanol Response To Cadmium Ion Inner Ear Development Anatomical Structure Development Regulation Of Synapse Organization Response To Glucocorticoid Response To CAMP Response To Calcium Ion	Skeletal System Development Morphogenesis Of A Branching Structure Endochondral Ossification Cell-matrix Adhesion Cell Differentiation Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Notochord Development Cell-cell Adhesion
Pathways		Platelet degranulation Nuclear signaling by ERBB4 ECM proteoglycans Scavenging by Class H Receptors	Collagen degradation Collagen biosynthesis and modifying enzymes Integrin cell surface interactions Collagen chain trimerization
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS			Adverse response to drug ( 30420678) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Carboplatin disposition in epthelial ovarian cancer ( 29367611) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Early childhood aggressive behavior ( 26087016) Middle childhood and early adolescence aggressive behavior ( 26087016) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Optic disc size ( 31809533) Parkinson's disease ( 23793441) PR interval ( 32439900) Response to fenofibrate (total cholesterol levels) ( 27002377) Ulcerative colitis ( 25082827) Upper eyelid morphology ( 29921221)
Interacting Genes		22 interacting genes: COL13A1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 CPEB2 CTSK FN1 HSPG2 PDGFA PDGFB PLAT PLG SDC2 TGFB1 TGM2 THBS1 UBQLN1 VEGFA XRCC6 ZNF579	7 interacting genes: FN1 HSPG2 ITGA1 MTDH NID1 NID2 SPARC
Entrez ID		6678	1305
HPRD ID		01631	00383
Ensembl ID		ENSG00000113140	ENSG00000197467
Uniprot IDs		P09486	Q5TAT6
PDB IDs		1BMO 1NUB 1SRA 2V53
Enriched GO Terms of Interacting Partners?
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