SP3 and SPANXN2

Data Source:
BioGRID (two hybrid)

		SP3	SPANXN2
Description		Sp3 transcription factor	SPANX family member N2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm PML Body Transcription Repressor Complex Protein-DNA Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Natural Killer Cell Differentiation Trophectodermal Cell Differentiation Liver Development Embryonic Placenta Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II B Cell Differentiation T Cell Differentiation Megakaryocyte Differentiation Monocyte Differentiation Lung Development Granulocyte Differentiation Enucleate Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Development Embryonic Process Involved In Female Pregnancy Definitive Hemopoiesis
Pathways		SUMOylation of transcription factors
Drugs
Diseases
GWAS		End-stage renal disease in Type 1 diabetics ( 24029427) Lung cancer ( 28604730) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Otitis media (chronic/recurrent) ( 23974705) QT interval ( 24952745 29874175) Sensation seeking ( 30718321)
Interacting Genes		29 interacting genes: AKT1 CIB3 E2F1 EP300 ESR1 GABPA GCH1 GRIN1 HDAC1 HDAC2 HLTF LIN54 NKX3-1 PHF21A PIAS1 POGZ RB1 RBBP4 RPS20 SNRPB SP1 SPANXN2 STK19 SUMO1 TP53 TP73 UBE2I VEGFA ZBTB7A	51 interacting genes: ANKRD1 ANKRD11 BANP BEND7 BHLHB9 BIVM CAVIN1 CDC14B CDCA8 CDYL2 COIL DPPA4 EPB41L3 FAM193B FAM204A H2BC11 H2BC15 H2BC21 KHDC4 KRCC1 L3MBTL3 MEOX2 MTIF3 NOL12 NUMB PBX4 PICK1 RPL27 RRP1 SFMBT1 SMN1 SMN2 SNIP1 SNRPD2 SP3 SP4 SRP14 STAC3 SYTL4 THAP1 TNNI1 VAX1 YAF2 ZBTB48 ZNF19 ZNF2 ZNF438 ZNF526 ZNF655 ZNF75A ZNF84
Entrez ID		6670	494119
HPRD ID		03483	18091
Ensembl ID		ENSG00000172845	ENSG00000268988
Uniprot IDs		B7ZLN9 Q02447 Q59FX5 Q86TP0	Q5MJ10
PDB IDs
Enriched GO Terms of Interacting Partners?
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