SOX5 and BCAT1

Data Source:
BioGRID (proximity labelling technology)

		SOX5	BCAT1
Description		SRY-box transcription factor 5	branched chain amino acid transaminase 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Mitochondrion Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding	Branched-chain-amino-acid Transaminase Activity Identical Protein Binding L-leucine Transaminase Activity L-valine Transaminase Activity L-isoleucine Transaminase Activity
	Biological Process	Cartilage Condensation Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Cartilage Development Asymmetric Neuroblast Division Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mesenchymal Stem Cell Differentiation	G1/S Transition Of Mitotic Cell Cycle Branched-chain Amino Acid Biosynthetic Process Branched-chain Amino Acid Catabolic Process Leucine Biosynthetic Process Valine Biosynthetic Process
Pathways			Branched-chain amino acid catabolism
Drugs			Pyridoxal phosphate Glutamic acid Leucine Valine Isoleucine N'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE
Diseases
GWAS		Adult body size ( 32376654) AIDS ( 19754311) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 29325848) Body mass index ( 25673413) Chronic back pain ( 30261039) Chronotype ( 30696823) Creatinine levels ( 29403010) Depression ( 29700475) Glomerular filtration rate ( 29403010) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heel bone mineral density ( 30598549) Height ( 28552196) Inflammatory bowel disease ( 27569725) Juvenile osteochondritis dissecans ( 26422391) LDL peak particle diameter (total fat intake interaction) ( 26112879) Mortality in sepsis ( 27639821) Non-obstructive azoospermia ( 22197933) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Pelvic organ prolapse (moderate/severe) ( 26545240) PR interval ( 29127183 30046033 32439900 20062060) Response to antipsychotic treatment ( 20195266) Response to statin therapy ( 20339536) Resting heart rate ( 29769521 27798624) Schizophrenia ( 29483656) Systemic sclerosis ( 21779181) Systolic blood pressure ( 30224653) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149)	Adventurousness ( 30643258) Atrial fibrillation ( 29892015) Body size at age 10 ( 32376654) Breast cancer ( 31757997) Calcium levels ( 25972035) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erythrocyte cadmium concentration ( 27005419) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) PR interval ( 30679814 32439900) Pulse pressure ( 30224653) Response to statin therapy ( 20339536) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Uterine fibroid size (maximum volume) ( 30196971)
Interacting Genes		36 interacting genes: APP ARID5A BIRC7 CAMK2A CBX8 CDC23 CDC25A CDK6 CRX FTH1 KAT5 KIFC3 LMO1 LMO2 MAGED1 MED27 MORN3 MSX2 PIAS2 PRR20A RNF4 RPS2 SMAD1 SMAD5 SMAD7 SOX6 SUMO1P1 TENT5B TEX11 TLE5 TRAF2 TTC1 UBE2I UQCRFS1 ZBTB26 ZNF581	7 interacting genes: C17orf75 ENKD1 KDM1A PRMT6 SMAD5 TRIM55 TRIM63
Entrez ID		6660	586
HPRD ID		18086	00216
Ensembl ID		ENSG00000134532	ENSG00000060982
Uniprot IDs		A0A024RB06 F5H0I3 P35711 T2CYZ2 T2CZM2	A0A024RAV0 P54687
PDB IDs			2ABJ 2COG 2COI 2COJ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?