SOX5 and SOX6

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SOX5	SOX6
Description		SRY-box transcription factor 5	SRY-box transcription factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Cartilage Condensation Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Cartilage Development Asymmetric Neuroblast Division Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mesenchymal Stem Cell Differentiation	Cartilage Condensation Chondrocyte Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Muscle Organ Development Spinal Cord Oligodendrocyte Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Astrocyte Differentiation Cartilage Development Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways			Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Adult body size ( 32376654) AIDS ( 19754311) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 29325848) Body mass index ( 25673413) Chronic back pain ( 30261039) Chronotype ( 30696823) Creatinine levels ( 29403010) Depression ( 29700475) Glomerular filtration rate ( 29403010) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heel bone mineral density ( 30598549) Height ( 28552196) Inflammatory bowel disease ( 27569725) Juvenile osteochondritis dissecans ( 26422391) LDL peak particle diameter (total fat intake interaction) ( 26112879) Mortality in sepsis ( 27639821) Non-obstructive azoospermia ( 22197933) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Pelvic organ prolapse (moderate/severe) ( 26545240) PR interval ( 29127183 30046033 32439900 20062060) Response to antipsychotic treatment ( 20195266) Response to statin therapy ( 20339536) Resting heart rate ( 29769521 27798624) Schizophrenia ( 29483656) Systemic sclerosis ( 21779181) Systolic blood pressure ( 30224653) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149)	Adolescent idiopathic scoliosis ( 30395268) Anti-saccade response ( 25387707) Blond vs. brown/black hair color ( 30531825) Blood pressure ( 23972371) Bone mineral density ( 24249740) Bone mineral density (hip) ( 19801982) Bone mineral density (wrist) ( 21104366) Capecitabine sensitivity ( 22864933) Chronotype ( 30696823) Coronary artery disease ( 29212778 33020668) Cotinine glucuronidation ( 25293881) Diastolic blood pressure ( 27841878 25249183 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Experiencing mood swings ( 29500382) Femoral neck bone mineral density ( 29499414 32239398 26367794 22504420) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) General factor of neuroticism ( 30867560) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hypertension ( 25249183) Left-handedness ( 32989287) Longevity (90 years and older) ( 25199915) Lumbar spine bone mineral density ( 26367794) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Multisite chronic pain ( 31194737) Neurociticism ( 29500382) Neuroticism ( 29255261) Obesity and osteoporosis ( 19714249) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systolic blood pressure ( 27841878 25249183 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 31046077)
Interacting Genes		36 interacting genes: APP ARID5A BIRC7 CAMK2A CBX8 CDC23 CDC25A CDK6 CRX FTH1 KAT5 KIFC3 LMO1 LMO2 MAGED1 MED27 MORN3 MSX2 PIAS2 PRR20A RNF4 RPS2 SMAD1 SMAD5 SMAD7 SOX6 SUMO1P1 TENT5B TEX11 TLE5 TRAF2 TTC1 UBE2I UQCRFS1 ZBTB26 ZNF581	12 interacting genes: CENPK CTBP2 DAZAP2 HDAC1 POMGNT1 SOX5 SUMO1 SUMO2 SUMO3 TRIP12 UBE2I ZNF184
Entrez ID		6660	55553
HPRD ID		18086	06267
Ensembl ID		ENSG00000134532	ENSG00000110693
Uniprot IDs		A0A024RB06 F5H0I3 P35711 T2CYZ2 T2CZM2	P35712
PDB IDs
Enriched GO Terms of Interacting Partners?
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