TRAK2 and KCNJ2

Data Source:
HPRD (two hybrid, in vivo)

		TRAK2	KCNJ2
Description		trafficking kinesin protein 2	potassium inwardly rectifying channel subfamily J member 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Early Endosome Plasma Membrane Dendrite Cytoplasmic Vesicle Dendrite Cytoplasm Neuronal Cell Body Axonal Growth Cone Axon Cytoplasm	Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Intercalated Disc T-tubule Intrinsic Component Of Membrane Neuronal Cell Body Dendritic Spine
	Molecular Function	Signaling Receptor Binding Protein Binding Myosin Binding Kinesin Binding Enzyme Binding TPR Domain Binding GABA Receptor Binding	Inward Rectifier Potassium Channel Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein O-linked Glycosylation Protein Targeting Endosome To Lysosome Transport Neurogenesis Vesicle Transport Along Microtubule Mitochondrion Distribution Dendrite Morphogenesis Negative Regulation Of Axonogenesis Anterograde Axonal Transport Of Mitochondrion Anterograde Dendritic Transport Of Mitochondrion	Potassium Ion Transport Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Magnesium Ion Transport Cellular Potassium Ion Homeostasis Regulation Of Ion Transmembrane Transport Protein Homotetramerization Relaxation Of Cardiac Muscle Regulation Of Resting Membrane Potential Regulation Of Membrane Repolarization Cardiac Conduction Cellular Response To Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Relaxation Of Skeletal Muscle Positive Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways			Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Ranolazine Miconazole Carvedilol Dronedarone
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Atrial fibrillation Short QT syndrome Andersen-Tawil syndrome (ATS)
GWAS		Breast cancer ( 31757997) Cocaine use disorder x change in residence interaction ( 31490055)	Adolescent idiopathic scoliosis (severe) ( 24023777) Atrial fibrillation ( 29892015) Birth weight ( 31043758) Chin dimples ( 27182965) Dentures ( 31235808) Depressive episodes in bipolar disorder ( 26297903) Early cardiac repolarization ( 22342860) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Formal thought disorder in schizophrenia ( 22648509) HDL cholesterol levels ( 32203549 32109663) Hip circumference adjusted for BMI ( 25673412) Lung function (forced vital capacity) ( 24929828) Macular thickness ( 30535121) Metabolite levels ( 23823483) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Prudent dietary pattern ( 28644415) Pulmonary function (smoking interaction) ( 23284291) QT interval ( 30679814 24952745 19305409 29874175) Refractive error ( 23396134) Renal overload gout ( 32238385) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) Thyrotoxic hypokalemic periodic paralysis ( 22863731 22399142) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) TPE interval (response to exercise) ( 32386560) TPE interval (resting) ( 32386560) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		3 interacting genes: GABRB2 KCNJ2 OGT	20 interacting genes: AKAP5 ARL13B CASK DLG1 DLG2 DLG3 DLG4 FLNA IL16 KCNJ11 KCNJ15 KCNJ16 KCNJ18 KCNJ4 KCNJ8 PATJ SDC3 SDCBP SEC22A TRAK2
Entrez ID		66008	3759
HPRD ID		09547	02815
Ensembl ID		ENSG00000115993	ENSG00000123700
Uniprot IDs		O60296	P63252
PDB IDs			6SPZ
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
Tagcloud (Intersection) ?