SLC22A1 and FXYD2

Data Source:
BioGRID (protein complementation assay)

		SLC22A1	FXYD2
Description		solute carrier family 22 member 1	FXYD domain containing ion transport regulator 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Presynapse	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Extracellular Exosome
	Molecular Function	Acetylcholine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Secondary Active Organic Cation Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity	ATPase Activator Activity Sodium Channel Regulator Activity Protein-macromolecule Adaptor Activity Ion Channel Regulator Activity
	Biological Process	Neurotransmitter Transport Drug Transmembrane Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transport Quaternary Ammonium Group Transport Norepinephrine Transport Xenobiotic Transport Epinephrine Transport Serotonin Uptake Norepinephrine Uptake Pyrimidine-containing Compound Transmembrane Transport Dopamine Uptake Cation Transmembrane Transport Transport Across Blood-brain Barrier Acetate Ester Transport Toxin Transport Xenobiotic Transport Across Blood-brain Barrier	Positive Regulation Of ATPase Activity Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Transmembrane Transport Positive Regulation Of Sodium:potassium-exchanging ATPase Activity Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Na+/Cl- dependent neurotransmitter transporters Organic cation transport	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs			Cyclothiazide Thimerosal
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels ( 28240269) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Essential hypertension (time to event) ( 32589924) Gout ( 22179738) HOMA-B (corrected for HOMA-IR) ( 30369944) LDL cholesterol levels ( 32203549) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipoprotein (a) levels ( 26377243) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic traits ( 21886157) Prostate cancer ( 26034056 21743057) Serum metabolite levels ( 23093944) Triglyceride levels ( 32203549) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995)	Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965) Refractive error ( 32231278)
Interacting Genes		27 interacting genes: ALDOA CAPN1 CCL2 CD63 CD9 CERS2 CHST12 CLPTM1 CYSTM1 FIS1 FXYD2 GHITM KRTCAP2 LAPTM4A LAPTM4B MUC1 PDZK1IP1 POU2AF1 SERP1 SLC25A11 SMIM24 SMIM3 SPP1 TMBIM4 TMEM147 TMEM179B VAPB	5 interacting genes: ATP1A1 ERGIC3 SGTA SLC22A1 SLC22A2
Entrez ID		6580	486
HPRD ID		04007	03487
Ensembl ID		ENSG00000175003	ENSG00000137731
Uniprot IDs		O15245	P54710
PDB IDs			2MKV
Enriched GO Terms of Interacting Partners?
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