SLC16A2 and EFNA5

Data Source:
BioGRID (two hybrid)

		SLC16A2	EFNA5
Description		solute carrier family 16 member 2	ephrin A5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane	Plasma Membrane Caveola Anchored Component Of External Side Of Plasma Membrane
	Molecular Function	Transporter Activity Monocarboxylic Acid Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Symporter Activity Thyroid Hormone Transmembrane Transporter Activity	Neurotrophin TRKA Receptor Binding Neurotrophin TRKB Receptor Binding Neurotrophin TRKC Receptor Binding Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Ephrin Receptor Binding
	Biological Process	Cellular Amino Acid Metabolic Process Monocarboxylic Acid Transport Thyroid Hormone Metabolic Process Sodium-independent Organic Anion Transport Thyroid Hormone Transport Amino Acid Import Across Plasma Membrane Transport Across Blood-brain Barrier Negative Regulation Of Neural Precursor Cell Proliferation	Positive Regulation Of Protein Phosphorylation Apoptotic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Nervous System Development Axon Guidance Regulation Of Cell-cell Adhesion Regulation Of Cell Morphogenesis Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Focal Adhesion Assembly Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Transport of organic anions	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		Pyruvic acid
Diseases		Allan-Herndon-Dudley syndrome; Monocarboxylate transporter 8 deficiency
GWAS			Adult body size ( 32376654) Alzheimer's disease biomarkers ( 23419831) Atrial fibrillation ( 29892015) Body mass index ( 26426971) Chronotype ( 30696823) Cocaine dependence ( 31212010) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Dentures ( 31235808) Hippocampal atrophy ( 19668339) Household income (MTAG) ( 31844048) Longitudinal cocaine use ( 31591132) Medial orbital frontal cortex volume ( 31530798) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Neonatal cytokine/chemokine levels (maternal genetic effect) ( 30134952) Non-del(5q) myelodysplastic syndromes ( 31738830) Nose morphology ( 29921221) Number of children ever born ( 27798627) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Sedentary behaviour duration ( 30531941) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		38 interacting genes: ADIPOQ ANKRD46 APOL3 BTN2A2 C3orf52 CCL2 CNIH3 COL4A5 CXCL16 CYB5B EFNA5 FAM3C JAGN1 LAT LEPROTL1 LHFPL5 LPAR3 MFSD6 MS4A13 PLP1 PNLIPRP1 SERPINA7 SLC30A2 SLC38A7 SLC39A13 SLC39A9 SMCO4 SYNGR1 THRA TMEM254 TMEM60 TOMM6 TRARG1 TSPO2 UNC93B1 UPK1B VAMP3 VEGFA	39 interacting genes: ACKR2 AQP2 AQP6 BEST2 CD53 CLDN5 CYB561 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 FFAR3 GJB1 GPR151 GPR152 GPR161 GPR42 GRIP1 HERPUD2 HIBADH KASH5 MS4A3 RHCG SGPL1 SLC10A2 SLC13A4 SLC16A2 SLC35C2 SRC SSMEM1 TM4SF18 TMEM237 TRHR TSPO2 YIPF6
Entrez ID		6567	1946
HPRD ID		02106	03324
Ensembl ID		ENSG00000147100	ENSG00000184349
Uniprot IDs		P36021	D6RDV5 P52803
PDB IDs			2X11 3MX0 4BK5 4BKA 4L0P 4M4R
Enriched GO Terms of Interacting Partners?
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