SLC12A2 and STK39

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		SLC12A2	STK39
Description		solute carrier family 12 member 2	serine/threonine kinase 39
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Membrane Apical Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Membrane Cell Projection Membrane Cell Projection Neuron Projection Neuronal Cell Body Cell Body Cell Body Membrane Extracellular Exosome Cell Periphery Spanning Component Of Membrane Extracellular Vesicle	Nucleoplasm Cytosol Cytoskeleton Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Sodium:potassium:chloride Symporter Activity Ammonium Transmembrane Transporter Activity Potassium Ion Transmembrane Transporter Activity Cation:chloride Symporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding Metal Ion Transmembrane Transporter Activity Chaperone Binding Hsp90 Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Ion Transport Cellular Sodium Ion Homeostasis Cell Volume Homeostasis Hyperosmotic Response Gamma-aminobutyric Acid Signaling Pathway Aging T Cell Chemotaxis Ammonium Transport Cellular Potassium Ion Homeostasis Transepithelial Chloride Transport Cellular Chloride Ion Homeostasis Maintenance Of Blood-brain Barrier Sodium Ion Transmembrane Transport Cellular Response To Potassium Ion Positive Regulation Of Cell Volume Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Negative Regulation Of Vascular Wound Healing Transepithelial Ammonium Transport Ammonium Transmembrane Transport Inorganic Anion Import Across Plasma Membrane Inorganic Cation Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Regulation Of Spontaneous Synaptic Transmission Transport Across Blood-brain Barrier Chloride Transmembrane Transport Positive Regulation Of Aspartate Secretion Regulation Of Matrix Metallopeptidase Secretion Potassium Ion Import Across Plasma Membrane Cellular Response To Chemokine	Activation Of MAPK Activity Protein Phosphorylation Signal Transduction Regulation Of Blood Pressure Positive Regulation Of T Cell Chemotaxis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Maintenance Of Lens Transparency Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Positive Regulation Of Potassium Ion Transport Protein Autophosphorylation Regulation Of Inflammatory Response Ion Homeostasis Cellular Hypotonic Response Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Creatine Transmembrane Transporter Activity Cellular Response To Chemokine Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Cation-coupled Chloride cotransporters
Drugs		Torasemide Potassium chloride Bumetanide Quinethazone	Fostamatinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Beard thickness ( 26926045) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) HDL cholesterol levels ( 32203549) Height ( 25282103 31562340) Ileal carcinoids ( 21139019) Immature fraction of reticulocytes ( 32888494) Pelvic organ prolapse ( 32184442) Red cell distribution width ( 28957414) Statin-induced myopathy ( 31220337)	Blood pressure ( 19114657) Body mass index ( 28552196 28892062) Macular thickness ( 30535121) Metabolite levels ( 23823483) Parkinson's disease ( 21292315 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Type 1 diabetes ( 32005708) Weight ( 28552196)
Interacting Genes		3 interacting genes: COMMD1 OXSR1 STK39	14 interacting genes: AATK GSN HSPH1 MAPK14 MBP OTOF PRKCQ RELT SLC12A1 SLC12A2 SLC12A6 SPP1 TSC22D2 WNK4
Entrez ID		6558	27347
HPRD ID		06775	09627
Ensembl ID		ENSG00000064651	ENSG00000198648
Uniprot IDs		B7ZM24 P55011 Q53ZR1	Q9UEW8
PDB IDs		6PZT
Enriched GO Terms of Interacting Partners?
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