BMP5 and CHRDL2

Data Source:
HPRD (in vivo)

		BMP5	CHRDL2
Description		bone morphogenetic protein 5	chordin like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Extracellular Space Vesicle	Extracellular Space Cytoplasm
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity BMP Receptor Binding
	Biological Process	Skeletal System Development Ossification Endocardial Cushion Formation Type B Pancreatic Cell Development Pericardium Morphogenesis Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process Neural Fold Elevation Formation BMP Signaling Pathway Hindbrain Development Negative Regulation Of Aldosterone Biosynthetic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Pharyngeal System Development SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Chorio-allantoic Fusion Heart Trabecula Morphogenesis Negative Regulation Of Mononuclear Cell Migration Positive Regulation Of Dendrite Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Allantois Development Negative Regulation Of Cortisol Biosynthetic Process	Ossification Cell Differentiation Cartilage Development
Pathways
Drugs
Diseases
GWAS		Colorectal cancer or advanced adenoma ( 30510241) Heel bone mineral density ( 30598549 28869591) Lean body mass ( 28552196) Zinc levels ( 26025379)	Allergic rhinitis ( 25085501) Blood protein levels ( 29875488) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Microalbuminuria ( 26631737) Spine bone size ( 31053729)
Interacting Genes		5 interacting genes: BMPR1A CHRDL2 FST MEOX2 NOG	21 interacting genes: BANP BMP2 BMP4 BMP5 BMP6 BMP7 CHRD ENKD1 FAH FAM90A1 GDF5 GPSM3 HOXA1 INHBA MAPRE3 OTX1 PIK3R3 POU4F2 SLIT1 ZNF417 ZNF587
Entrez ID		653	25884
HPRD ID		00210	09881
Ensembl ID		ENSG00000112175	ENSG00000054938
Uniprot IDs		A8K694 M9VUD0 P22003	Q6WN34
PDB IDs
Enriched GO Terms of Interacting Partners?
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