WNK2 and WNK1

Data Source:
BioGRID (two hybrid)

		WNK2	WNK1
Description		WNK lysine deficient protein kinase 2	WNK lysine deficient protein kinase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Cytoplasm Cytosol Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Phosphatase Binding Protein Kinase Activator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Sodium Ion Transport Intracellular Signal Transduction Protein Autophosphorylation Ion Homeostasis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Regulation Of Sodium Ion Transport Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Ion Transport Signal Transduction Negative Regulation Of Sodium Ion Transport Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Phosphatase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Activation Of Protein Kinase Activity Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of GTPase Activity Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Neuron Development Regulation Of Cellular Process Ion Homeostasis T Cell Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Lymphocyte Migration Into Lymph Node Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Potassium Ion Import Across Plasma Membrane Regulation Of Cation Transmembrane Transport Cellular Response To Chemokine Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Stimuli-sensing channels	Stimuli-sensing channels
Drugs
Diseases			Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Ability to confide in someone ( 29970889) Bipolar disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Perceived sweetness of sucrose ( 31005972)	Adult body size ( 32376654) Blood protein levels ( 29875488) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Manganese levels ( 26025379) Monocyte percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Squamous cell lung carcinoma ( 28604730) Stroke ( 19369658)
Interacting Genes		5 interacting genes: ATXN1 ESS2 MTDH WNK1 YWHAZ	36 interacting genes: ADRB2 AKT1 ARAF ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 KLHL3 MAP2K1 MAP3K2 MAP3K3 MT-ATP8 PFKP PRKAR1A PRKAR1B PVR RANBP9 SLC9A1 SYT2 TNRC6A TSC22D1 TULP3 UBE2I UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX
Entrez ID		65268	65125
HPRD ID		06951	05570
Ensembl ID		ENSG00000165238	ENSG00000060237
Uniprot IDs		F8W9F9 Q9Y3S1	A5D8Z4 F5GWT4 Q9H4A3
PDB IDs		6ELM 6FBK	4PWN 5TF9 5WDY 5WE8 6FBK
Enriched GO Terms of Interacting Partners?
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