ACD and PFKP

Data Source:
BioGRID (two hybrid)

		ACD	PFKP
Description		ACD shelterin complex subunit and telomerase recruitment factor	phosphofructokinase, platelet
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Telomerase Holoenzyme Complex Nuclear Body Shelterin Complex	Nucleus Cytoplasm Cytosol 6-phosphofructokinase Complex Membrane Extracellular Exosome
	Molecular Function	Protein Binding Telomeric DNA Binding Protein-containing Complex Binding DNA Polymerase Binding	6-phosphofructokinase Activity Protein Binding ATP Binding AMP Binding Identical Protein Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding Monosaccharide Binding Fructose-6-phosphate Binding
	Biological Process	Telomere Maintenance Intracellular Protein Transport Telomere Maintenance Via Telomerase Telomere Capping Protection From Non-homologous End Joining At Telomere Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity Positive Regulation Of Single-stranded Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Telomere	Fructose 6-phosphate Metabolic Process Fructose 1,6-bisphosphate Metabolic Process Canonical Glycolysis Cellular Response To Leukemia Inhibitory Factor
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Glycolysis
Drugs
Diseases
GWAS		Hemoglobin levels ( 32327693) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Body size at age 10 ( 32376654) Disc degeneration (lumbar) ( 22993228) Hippocampal volume in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Scalp hair shape ( 26926045) Subclinical trait of interstitial lung disease (percentage of high attenuation areas on CT scan) ( 28521775)
Interacting Genes		63 interacting genes: ACTB ADPRH AFAP1L2 AIPL1 ANKMY2 ANXA8L1 APOBEC3F BAG3 CKB CTTN DBN1 DBNL DCX DPYSL3 EIF3G EIF4B ENO2 ENSA FAM131B FKBP6 GAPDH HSP90AB1 IPO5 IVL LASP1 LDHA LGALSL LLGL1 LRRC25 NCDN NTAQ1 NUDC NUDCD2 PAGE2 PDLIM2 PEX5 PFKP PGM2 POT1 RBKS RECQL4 RGS3 RPSA SBDS STIP1 STUB1 SULT1C2 TAGLN TBC1D10A TBCD TINF2 TOMM34 TRIM15 TRIM16 TRIM55 TRIM63 TUBB2A TUBB4B USP7 XRCC6 YWHAE ZFP36L1 ZNF790	13 interacting genes: ACD AGO2 AKT1 DYNLL1 EGFR KAT5 NUTF2 POT1 SUMO2 TERF1 TINF2 TRIM21 WNK1
Entrez ID		65057	5214
HPRD ID		12417	01384
Ensembl ID		ENSG00000102977	ENSG00000067057
Uniprot IDs		A0A590TQL1 Q96AP0	B1APP6 Q01813
PDB IDs		2I46 5H65 5I2X 5I2Y 5UN7 5XYF	4RH3 4U1R 4WL0 4XYJ 4XYK 4XZ2
Enriched GO Terms of Interacting Partners?
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