ST3GAL3 and POU3F1

Data Source:
BioGRID (affinity chromatography technology)

		ST3GAL3	POU3F1
Description		ST3 beta-galactoside alpha-2,3-sialyltransferase 3	POU class 3 homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Integral Component Of Membrane Golgi Cisterna Membrane	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Protein Binding N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Glycosylation O-glycan Processing Keratan Sulfate Biosynthetic Process Sialylation	Regulation Of Transcription By RNA Polymerase II Axon Ensheathment Positive Regulation Of Gene Expression Myelination In Peripheral Nervous System Keratinocyte Differentiation Forebrain Development Positive Regulation Of Transcription, DNA-templated
Pathways		Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Aging (time to event) ( 21782286) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Attention deficit hyperactivity disorder ( 29325848) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) General cognitive ability ( 29844566) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Left-handedness ( 32989287) Monocyte percentage of white cells ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Refractive error ( 32231278) Schizophrenia ( 28991256)	Rheumatoid arthritis ( 23143596 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-to-hip circumference ratio (ever vs never smoking interaction) ( 23192594)
Interacting Genes		5 interacting genes: ACTG1 RPL8 SCAMP2 TTR ZBTB5	3 interacting genes: HMGA1 HMGB2 POU3F4
Entrez ID		6487	5453
HPRD ID		05930	03921
Ensembl ID		ENSG00000126091	ENSG00000185668
Uniprot IDs		A0A2R8Y732 Q11203	Q03052
PDB IDs
Enriched GO Terms of Interacting Partners?
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