KLC2 and DYNC1I1

Data Source:
BioGRID (affinity chromatography technology)

		KLC2	DYNC1I1
Description		kinesin light chain 2	dynein cytoplasmic 1 intermediate chain 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol Kinesin Complex Microtubule Plasma Membrane Membrane Kinesin I Complex Protein-containing Complex	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Cytoplasm Cytosol Cytoplasmic Dynein Complex Microtubule Vesicle Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Protein Binding Kinesin Binding Cadherin Binding	Motor Activity Microtubule Motor Activity Protein Binding Microtubule Binding Spectrin Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule-based Movement Transport Along Microtubule Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Vesicle Transport Along Microtubule
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756) Metabolite levels ( 23823483)	Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Immune reponse to smallpox (secreted IL-10) ( 22610502) Knee osteoarthritis ( 27696742) Multisite chronic pain ( 31194737) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Refractive error ( 32231278)
Interacting Genes		16 interacting genes: AIMP2 APP CLSTN1 COIL DDX41 KIF2A KLC1 KLC4 LRRK2 MAPK8IP3 PIK3R3 PRC1 S100A8 YWHAG YWHAQ YWHAZ	31 interacting genes: ANXA7 BICD1 CADM4 CDKN1A DNM2 DYNLL1 DYNLL2 DYNLRB1 DYNLT1 DYNLT3 EMILIN1 FAM110A FAM83D FBP1 GRB7 GSK3B KAT7 MCC NAGK NDEL1 NUDT21 PIN1 RAP1GAP RCC1 RUNDC3B SMN1 STAU1 TAOK1 TK1 TRIM58 WDCP
Entrez ID		64837	1780
HPRD ID		13917	04798
Ensembl ID		ENSG00000174996	ENSG00000158560
Uniprot IDs		Q9H0B6	A4D1I7 O14576 Q8N542
PDB IDs		3CEQ 3EDT
Enriched GO Terms of Interacting Partners?
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