DYNC1I1 and TRIM58

Data Source:
BioGRID (enzymatic study)

		DYNC1I1	TRIM58
Description		dynein cytoplasmic 1 intermediate chain 1	tripartite motif containing 58
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Cytoplasm Cytosol Cytoplasmic Dynein Complex Microtubule Vesicle Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Recycling Endosome	Cytoplasm
	Molecular Function	Motor Activity Microtubule Motor Activity Protein Binding Microtubule Binding Spectrin Binding Dynein Light Chain Binding Dynein Heavy Chain Binding	Molecular_function Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule-based Movement Transport Along Microtubule Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Vesicle Transport Along Microtubule	Biological_process Regulation Of Gene Expression Protein Ubiquitination Innate Immune Response
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Immune reponse to smallpox (secreted IL-10) ( 22610502) Knee osteoarthritis ( 27696742) Multisite chronic pain ( 31194737) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Refractive error ( 32231278)	Blood metabolite levels ( 26401656) Blood protein levels ( 28240269) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 28453575 20139978 27863252 28017375) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 22139419 29403010 32888494 27863252) Platelet distribution width ( 32888494 27863252) Red blood cell count ( 32888494 27863252) Red blood cell fatty acid levels ( 25500335) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systemic juvenile idiopathic arthritis ( 27927641) White blood cell count ( 32888494 27863252)
Interacting Genes		31 interacting genes: ANXA7 BICD1 CADM4 CDKN1A DNM2 DYNLL1 DYNLL2 DYNLRB1 DYNLT1 DYNLT3 EMILIN1 FAM110A FAM83D FBP1 GRB7 GSK3B KAT7 MCC NAGK NDEL1 NUDT21 PIN1 RAP1GAP RCC1 RUNDC3B SMN1 STAU1 TAOK1 TK1 TRIM58 WDCP	2 interacting genes: DYNC1I1 UBE2D3
Entrez ID		1780	25893
HPRD ID		04798	09825
Ensembl ID		ENSG00000158560	ENSG00000162722
Uniprot IDs		A4D1I7 O14576 Q8N542	Q8NG06
PDB IDs
Enriched GO Terms of Interacting Partners?
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