CCDC136 and ISCU

Data Source:
BioGRID (two hybrid)

		CCDC136	ISCU
Description		coiled-coil domain containing 136	iron-sulfur cluster assembly enzyme
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Membrane Integral Component Of Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function		Iron Ion Binding Protein Binding Ferrous Iron Binding 2 Iron, 2 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding Molecular Adaptor Activity
	Biological Process	Acrosome Assembly Spermatogenesis Single Fertilization	Cellular Iron Ion Homeostasis Iron-sulfur Cluster Assembly Small Molecule Metabolic Process Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Aconitate Hydratase Activity Negative Regulation Of Iron Ion Import Across Plasma Membrane
Pathways
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)	Acne (severe) ( 24927181) Intraocular pressure ( 29617998)
Interacting Genes		136 interacting genes: ABT1 AQP1 ASB7 ATP5PO ATXN1 BARD1 BLOC1S6 BYSL C1orf216 C21orf58 CARD9 CBX8 CCDC120 CCDC13 CCDC146 CCDC185 CCDC187 CCDC6 CCHCR1 CDC5L CDK2AP1 CEP57 CEP57L1 CEP95 COIL CWF19L2 DDX6 DISC1 DTNB DYNC1I2 ENKD1 FAM107A FAM161A FAM161B FAM50B FLYWCH1 GFI1B HAUS1 HDAC4 HGS HMG20A HMG20B HOXB5 ISCU JAKMIP2 JMY JRK KANSL1 KAT5 KIF5B KIFC3 LCA5L LENG1 MAGEB4 MBD3L2 MCRS1 MOS NDC80 NDN NEBL NEK6 NME7 NOP53 ODAD3 PDLIM5 PIBF1 PKN1 PKN2 POGZ PPP1R18 PRPF18 PRPF3 PRPF31 PRR35 PSMA1 PSMC5 PSMD9 RAB33A RAB33B RALBP1 RASAL3 RASSF8 SCNM1 SDHAF1 SHFL SMARCE1 SYT6 TBRG1 TCEA2 THAP7 TNNT1 TRAF3IP3 TSGA10 TSGA10IP TSPYL1 TXLNA UBQLN4 UBTFL1 USP2 WT1 ZBTB24 ZBTB38 ZBTB47 ZC2HC1C ZFP1 ZFYVE26 ZNF124 ZNF20 ZNF223 ZNF230 ZNF250 ZNF264 ZNF329 ZNF35 ZNF408 ZNF417 ZNF440 ZNF490 ZNF497 ZNF564 ZNF572 ZNF580 ZNF581 ZNF587 ZNF599 ZNF648 ZNF669 ZNF670 ZNF688 ZNF696 ZNF774 ZNF777 ZNF785 ZNF835 ZNF837 ZSCAN26	17 interacting genes: AGTRAP BANP CBY2 CCDC136 CCDC172 FAM9B GOLGA2 GOLGA6L9 HPRT1 IKZF1 KRT34 KRT40 LNX1 MID2 NECAB2 NUP62 PICK1
Entrez ID		64753	23479
HPRD ID		10887	14828
Ensembl ID		ENSG00000128596	ENSG00000136003
Uniprot IDs		A0A024R758 Q96JN2	A0A024RBI3 B1P7G3 B3KQ30 B4DNC9 Q9H1K1
PDB IDs			5KZ5 5WKP 5WLW 6NZU 6UXE 6W1D 6WI2 6WIH
Enriched GO Terms of Interacting Partners?
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