SH3BP2 and DBNL

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		SH3BP2	DBNL
Description		SH3 domain binding protein 2	drebrin like
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GO Annotations	Cellular Component		Golgi Membrane Ruffle Podosome Extracellular Region Cytoplasm Early Endosome Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Lamellipodium Dendrite Site Of Polarized Growth Clathrin-coated Vesicle Membrane Cortical Actin Cytoskeleton Secretory Granule Lumen Perikaryon Postsynaptic Membrane Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding SH3 Domain Binding	Actin Binding Protein Binding Protein C-terminus Binding Enzyme Activator Activity Protein Domain Specific Binding Cadherin Binding Actin Filament Binding
	Biological Process	Signal Transduction	Adaptive Immune Response Receptor-mediated Endocytosis Activation Of JUN Kinase Activity Synapse Assembly Rac Protein Signal Transduction Regulation Of Actin Filament Polymerization Neutrophil Degranulation Positive Regulation Of Axon Extension Neuron Projection Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Podosome Assembly Ruffle Assembly Postsynaptic Actin Cytoskeleton Organization
Pathways			Caspase-mediated cleavage of cytoskeletal proteins Neurexins and neuroligins Neutrophil degranulation
Drugs
Diseases		Cherubism
GWAS		Huntington's disease progression ( 28642124) Multiple sclerosis ( 24076602)	Blood protein levels ( 30072576)
Interacting Genes		31 interacting genes: ABL1 ARHGAP10 CTTN DBNL ERBB2 ERBB3 ERBB4 FGFR1 FLT3 FYN GRB2 HCLS1 KIT LAT LCK MET MYO1F PDLIM7 PLCG1 PLCG2 SH3KBP1 SH3RF1 STAT3 SYK TF TNKS2 VAV1 VAV2 VAV3 YWHAQ ZAP70	12 interacting genes: ACD CASP3 HOMER1 MAP4K1 NEURL4 POT1 SH2D4A SH3BP2 SYK TERF1 TERF2IP ZAP70
Entrez ID		6452	28988
HPRD ID		03657	06588
Ensembl ID		ENSG00000087266	ENSG00000136279
Uniprot IDs		A0A384N6E5 P78314	B4DUF9 Q9UJU6
PDB IDs		2CR4 3TWR	1X67
Enriched GO Terms of Interacting Partners?
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