ATG3 and ATG12

Data Source:
HPRD (in vivo)

		ATG3	ATG12
Description		autophagy related 3	autophagy related 12
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GO Annotations	Cellular Component	Cytoplasmic Ubiquitin Ligase Complex Cytosol	Autophagosome Cytosol Phagocytic Vesicle Membrane Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex
	Molecular Function	Protein Binding Atg8 Ligase Activity Atg12 Transferase Activity Ubiquitin-like Protein Transferase Activity Enzyme Binding	Protein Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Cellular Protein Modification Process Protein Targeting To Membrane Macroautophagy Protein Ubiquitination Protein Phosphopantetheinylation Mitochondrial Fragmentation Involved In Apoptotic Process Autophagy Of Nucleus Negative Regulation Of Phagocytosis Regulation Of Cilium Assembly	Autophagosome Assembly Autophagy Of Mitochondrion C-terminal Protein Lipidation Viral Process Macroautophagy Autophagy Of Nucleus
Pathways		Macroautophagy	Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 23829686)
Interacting Genes		7 interacting genes: ATG12 ATG7 BECN1 GABARAP GABARAPL2 MAP1LC3B MOB2	15 interacting genes: APP ATG10 ATG3 ATG5 ATG7 CRX DOCK9 IER2 KRTAP4-12 MDFI MEOX2 PLSCR1 PTK2 SERTAD1 SERTAD2
Entrez ID		64422	9140
HPRD ID		10654	08496
Ensembl ID		ENSG00000144848	ENSG00000145782
Uniprot IDs		Q9NT62	O94817
PDB IDs		4NAW	4GDK 4GDL 4NAW
Enriched GO Terms of Interacting Partners?
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