ARHGEF28 and MAPK8IP1

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		ARHGEF28	MAPK8IP1
Description		Rho guanine nucleotide exchange factor 28	mitogen-activated protein kinase 8 interacting protein 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Mitochondrial Membrane Dendritic Growth Cone Axonal Growth Cone Cell Body Dentate Gyrus Mossy Fiber Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Metal Ion Binding	Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Cell Morphogenesis Cell Differentiation Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Catalytic Activity	Regulation Of Transcription, DNA-templated JUN Phosphorylation Vesicle-mediated Transport Negative Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		EPHB-mediated forward signaling
Drugs			Pyrazolanthrone 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE Anthralin
Diseases
GWAS		Chin dimples ( 27182965) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) HDL cholesterol ( 30275531) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: CTAG1A CTAG1B MAPK8IP1 RHOA YWHAE YWHAH	26 interacting genes: AKT1 APP ARHGEF28 DUSP16 EGFR ERBB2 KLC1 LRP1 LRP2 LRP8 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K7 MAPK8 MAPK8IP2 MAPK8IP3 MAPK9 PARK7 PAX2 RECQL5 SNCA TIAM1 VRK2
Entrez ID		64283	9479
HPRD ID		15244	05223
Ensembl ID		ENSG00000214944	ENSG00000121653
Uniprot IDs		Q8N1W1	Q6NUQ9 Q9UQF2
PDB IDs		6BC0 6BC1	2G01 2GMX 2H96 3OXI 3PTG 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4E73 4G1W 4H39 4HYS 4HYU 4IZY 5LW1 6FUZ
Enriched GO Terms of Interacting Partners?
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