SEMA4A and HAVCR1

Data Source:
HPRD (in vivo, in vitro)

		SEMA4A	HAVCR1
Description		semaphorin 4A	hepatitis A virus cellular receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Cell Surface Integral Component Of Membrane Motile Cilium
	Molecular Function	Protein Binding Semaphorin Receptor Binding Chemorepellent Activity	Virus Receptor Activity Phosphatidylserine Binding
	Biological Process	Angiogenesis Neural Crest Cell Migration Axon Guidance Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration T-helper 1 Cell Differentiation Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Semaphorin-plexin Signaling Pathway Positive Regulation Of Excitatory Synapse Assembly Positive Regulation Of Inhibitory Synapse Assembly	Phagocytosis, Engulfment Positive Regulation Of Mast Cell Activation Viral Entry Into Host Cell
Pathways		Other semaphorin interactions
Drugs
Diseases		Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Retinitis pigmentosa (RP)
GWAS		Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 32888494) Stroke ( 29531354) Systolic blood pressure ( 30224653)	Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Cholesterol, total ( 25961943 20686565) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 19060906 25961943 20686565) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731 29593015) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577) Total cholesterol levels ( 29403010) Triglyceride levels ( 32154731) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 25961943 20686565)
Interacting Genes		3 interacting genes: DDX54 HAVCR1 PLXND1	3 interacting genes: DYNLT1 SEMA4A UBQLN4
Entrez ID		64218	26762
HPRD ID		09528	09404
Ensembl ID		ENSG00000196189	ENSG00000113249
Uniprot IDs		B4DKS5 Q9H3S1	B4DPB1 E9PFX0 Q96D42
PDB IDs			5DZO 5F70
Enriched GO Terms of Interacting Partners?
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