DNAJC1 and ITIH4

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		DNAJC1	ITIH4
Description		DnaJ heat shock protein family (Hsp40) member C1	inter-alpha-trypsin inhibitor heavy chain 4
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Nuclear Membrane	Extracellular Region Platelet Dense Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	ATPase Activator Activity DNA Binding Protein Binding Chaperone Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Regulation Of Translation Protein Folding Positive Regulation Of ATPase Activity Negative Regulation Of Proteolysis Regulation Of Protein Secretion	Platelet Degranulation Acute-phase Response Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process Response To Cytokine
Pathways			Platelet degranulation
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Essential hypertension (time to event) ( 32589924) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Oily fish consumption ( 32066663) Ovarian cancer ( 23535730) Pork consumption ( 32066663) Raw vegetable consumption ( 32066663) Subcutaneous adipose tissue ( 26480920) Urinary albumin-to-creatinine ratio ( 31511532)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Blood protein levels ( 30072576) Body mass index ( 28552196 24861553) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-2) ( 22610502) Manganese levels ( 26025379) Neurological blood protein biomarker levels ( 31320639) Parkinson's disease ( 28892059) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 25056061 21926974 29483656 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 23128233)
Interacting Genes		11 interacting genes: ABHD16A AGTRAP ATP6V0C CMTM7 CYP4F2 HSPA5 ITIH4 PLP2 SERPINA3 TMEM201 TNFRSF10C	4 interacting genes: DNAJC1 GRB2 KLK1 TP63
Entrez ID		64215	3700
HPRD ID		09922	02781
Ensembl ID		ENSG00000136770	ENSG00000055955
Uniprot IDs		Q96KC8	B2RMS9 B7ZKJ8 Q14624
PDB IDs		2CQQ 2CQR
Enriched GO Terms of Interacting Partners?
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