NOD2 and ANKHD1

Data Source:
BioGRID (fluorescent resonance energy transfer)

		NOD2	ANKHD1
Description		nucleotide binding oligomerization domain containing 2	ankyrin repeat and KH domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Basolateral Plasma Membrane Vesicle Protein-containing Complex Phagocytic Vesicle Anchored Component Of Plasma Membrane	Cytoplasm
	Molecular Function	Actin Binding Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Hsp70 Protein Binding Muramyl Dipeptide Binding Pattern Recognition Receptor Activity Peptidoglycan Binding Protein-containing Complex Binding CARD Domain Binding Hsp90 Protein Binding	RNA Binding Protein Binding
	Biological Process	Activation Of MAPK Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response In Mucosa Activation Of Immune Response Cytokine Production Involved In Immune Response Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Type 2 Immune Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Defense Response Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria JNK Cascade Response To Nutrient Detection Of Biotic Stimulus Detection Of Bacterium Maintenance Of Gastrointestinal Epithelium Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Detection Of Muramyl Dipeptide Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Intracellular Signal Transduction Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Gamma-delta T Cell Activation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Neutrophil Chemotaxis Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Xenophagy Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Prostaglandin-E Synthase Activity	Innate Immune Response
Pathways		NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling
Drugs		Mifamurtide
Diseases		Blau syndrome Crohn's disease
GWAS		Asthma ( 31361310 30929738 32296059) Asthma (childhood onset) ( 31036433 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17554300 21102463 23128233 17804789) Inflammatory bowel disease ( 18758464 28067908) Leprosy ( 20018961 27976721 25642632) Medication use (thyroid preparations) ( 31015401) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Serum immune biomarker levels ( 32066700)
Interacting Genes		38 interacting genes: ALPI ANKHD1 ANXA2 ATG16L1 C10orf67 CCL13 CHMP4B CHMP5 DCTN1 DOCK7 ENTR1 ERBIN GOLGA6L5P GOLGB1 HAP1 IKBIP IRGM LDOC1 LMNA LURAP1L MAP3K7 NLRC4 PDLIM5 PPP1R12C PPP2R3B PRR16 RIPK2 RPL13A SCYL1 TACC3 TNIP1 TPM1 TPM3 TPM4 TRIM41 VCP WBP11 XIAP	17 interacting genes: ATXN1 ATXN1L FHL3 GOLGA2 KRTAP15-1 KRTAP19-5 LENG8 NFKBIE NOD2 POLR2M PRR20A PRR20B PRR20C PRR20D PRR20E ZNF34 ZNF346
Entrez ID		64127	54882
HPRD ID		05810	16489
Ensembl ID		ENSG00000167207	ENSG00000131503
Uniprot IDs		A0A286YF65 Q9HC29	Q8IWZ3
PDB IDs
Enriched GO Terms of Interacting Partners?
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