PRDM16 and RIOK2

Data Source:
BioGRID (two hybrid)

		PRDM16	RIOK2
Description		PR/SET domain 16	RIO kinase 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Aggresome Transcription Repressor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Preribosome, Small Subunit Precursor
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Activating Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)	Protein Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Respiration Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Brown Fat Cell Differentiation Histone H3-K9 Methylation Heterochromatin Organization Positive Regulation Of Cold-induced Thermogenesis	Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Maturation Of SSU-rRNA Ribosomal Small Subunit Biogenesis Protein Autophosphorylation Positive Regulation Of Ribosomal Small Subunit Export From Nucleus Positive Regulation Of RRNA Processing
Pathways		PKMTs methylate histone lysines	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs			Fostamatinib
Diseases
GWAS		Allergic rhinitis ( 25085501) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline (age-related) ( 28078323) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27618448) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hypertension ( 31879980) Immature fraction of reticulocytes ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27182965 23793025 21666692 27322543) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Motion sickness ( 25628336) Nicotine dependence symptom count ( 25555482) Nose morphology ( 29921221) Optic disc size ( 31809533) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) QRS duration ( 25035420) Red blood cell count ( 32888494 27863252) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 30891314) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27618448) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Chronic mountain sickness ( 31417607) Metabolite levels ( 23823483)
Interacting Genes		22 interacting genes: ACOT8 ARRB1 CCDC13 CFAP206 DDX6 GLMN LENG8 LONRF1 MID2 MIPOL1 NEK6 PATJ PLK4 POLR3C RBBP4 RIOK2 RUNX1T1 TCHP TEX10 TSG101 TXLNA XPA	7 interacting genes: APP CSNK2A1 GFUS PRDM16 RELA RPRD1A SMAD3
Entrez ID		63976	55781
HPRD ID		16122	10193
Ensembl ID		ENSG00000142611	ENSG00000058729
Uniprot IDs		Q9HAZ2	Q9BVS4
PDB IDs		2N1I 6BW4	5DHF 6FDM 6FDN 6FDO 6G18 6G51 6HK6
Enriched GO Terms of Interacting Partners?
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