SCNN1A and SERP1

Data Source:
BioGRID (protein complementation assay)

		SCNN1A	SERP1
Description		sodium channel epithelial 1 subunit alpha	stress associated endoplasmic reticulum protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Motile Cilium Sodium Channel Complex Ciliary Membrane Extracellular Exosome Sperm Principal Piece	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Ribosome Cytoplasmic Microtubule Integral Component Of Membrane
	Molecular Function	Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding	Protein Binding
	Biological Process	Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis	Cellular Protein Modification Process Protein Glycosylation Plasma Membrane Organization Protein Transport Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response
Pathways		Stimuli-sensing channels	XBP1(S) activates chaperone genes Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Triamterene Amiloride
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome) Bronchiectasis with or without elevated sweat chloride
GWAS		Adverse response to drug ( 30420678) Alopecia areata ( 25608926) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity (early onset extreme) ( 23563609) Primary biliary cirrhosis ( 22961000)
Interacting Genes		17 interacting genes: COMMD10 CSNK2A1 EPN1 HECW1 ITCH NEDD4 NEDD4L SCNN1B SCNN1G SERP1 SNX3 STX1A TSG101 UBE2I USP10 WWP1 WWP2	52 interacting genes: ALG3 APH1A APP AQP6 AQP8 BIK BSCL2 CANX CD74 CD79A CRB3 CYBRD1 EBP FAM174A FAM209A FAM210B FRMD3 GJB3 GJB5 GKN1 GPR37L1 GPX8 HSD17B13 IL3RA JAGN1 KCNF1 KIR3DL3 LHFPL5 LMNA MFSD14B MTIF3 PLPPR1 REEP4 SAR1A SCNN1A SCNN1G SEC11C SEC61A1 SEC61B SLC10A6 SLC22A1 SLC22A2 SLC35C2 SSMEM1 STX1A STX2 STX4 TLCD4 TMEM14B TMEM52B TMEM79 TNFRSF9
Entrez ID		6337	27230
HPRD ID		02575	18037
Ensembl ID		ENSG00000111319	ENSG00000120742
Uniprot IDs		P37088	Q9Y6X1
PDB IDs		2M3O 6BQN 6WTH
Enriched GO Terms of Interacting Partners?
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