SCN8A and FGF13

Data Source:
HPRD (two hybrid, in vivo)

		SCN8A	FGF13
Description		sodium voltage-gated channel alpha subunit 8	fibroblast growth factor 13
Image		No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Z Disc Cell Junction Axon Cytoplasmic Vesicle Node Of Ranvier Axon Initial Segment	Extracellular Region Nucleus Nucleolus Cytoplasm Cytosol Microtubule Plasma Membrane Intercalated Disc Lateral Plasma Membrane Filopodium Axon Dendrite Growth Cone Neuron Projection
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding ATP Binding	Protein Binding Microtubule Binding Growth Factor Activity Sodium Channel Regulator Activity Protein Kinase Activator Activity Ion Channel Binding Beta-tubulin Binding
	Biological Process	Sodium Ion Transport Nervous System Development Peripheral Nervous System Development Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Membrane Depolarization During Action Potential	MAPK Cascade Neuron Migration Sodium Ion Transport Negative Regulation Of Microtubule Depolymerization Signal Transduction Cell-cell Signaling Nervous System Development Learning Memory Hippocampus Development Cerebral Cortex Cell Migration Activation Of Protein Kinase Activity Establishment Of Neuroblast Polarity Microtubule Polymerization Negative Regulation Of Collateral Sprouting Protein Localization To Plasma Membrane Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Inhibitory Synapse Assembly Regulation Of Voltage-gated Sodium Channel Activity
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	Phase 0 - rapid depolarisation
Drugs		Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Promethazine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol use disorder (consumption score) ( 30940813) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Response to antidepressants and depression ( 27622933)	Breast cancer in BRCA2 mutation carriers ( 23544012) Response to taxane treatment (placlitaxel) ( 23006423)
Interacting Genes		4 interacting genes: FGF13 FGF14 GNAO1 MAPK14	7 interacting genes: APP FBXO7 MAPK8IP2 PLEKHF2 PRNP PSEN1 SCN8A
Entrez ID		6334	2258
HPRD ID		09006	02090
Ensembl ID		ENSG00000196876	ENSG00000129682
Uniprot IDs		Q6B4S4 Q9UQD0	A8K1P5 Q92913
PDB IDs			3HBW 4DCK 4JPZ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?