SCN5A and RGS2

Data Source:
HPRD (two hybrid)

		SCN5A	RGS2
Description		sodium voltage-gated channel alpha subunit 5	regulator of G protein signaling 2
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GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Nucleoplasm Nucleolus Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Intercalated Disc Integral Component Of Membrane Lateral Plasma Membrane Z Disc T-tubule Sarcolemma Perinuclear Region Of Cytoplasm	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Neuron Projection
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Calmodulin Binding Fibroblast Growth Factor Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ankyrin Binding Ubiquitin Protein Ligase Binding Ion Channel Binding Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Bundle Of His Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential Voltage-gated Sodium Channel Activity Involved In SA Node Cell Action Potential Scaffold Protein Binding	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding Beta-tubulin Binding
	Biological Process	Regulation Of Heart Rate Cardiac Ventricle Development Brainstem Development Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Response To Denervation Involved In Regulation Of Muscle Adaptation Neuronal Action Potential Telencephalon Development Cerebellum Development Sodium Ion Transmembrane Transport Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Action Potential Positive Regulation Of Epithelial Cell Proliferation Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Cellular Response To Calcium Ion Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential AV Node Cell Action Potential Bundle Of His Cell Action Potential Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Membrane Depolarization During Bundle Of His Cell Action Potential AV Node Cell To Bundle Of His Cell Communication Regulation Of Heart Rate By Cardiac Conduction Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport	Response To Amphetamine Cell Cycle G Protein-coupled Receptor Signaling Pathway Spermatogenesis Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Phospholipase Activity Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Neuron Projection Development Negative Regulation Of Translation Ovulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Negative Regulation Of CAMP-mediated Signaling Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Associated Smooth Muscle Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Glycine Import Across Plasma Membrane
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	G alpha (q) signalling events
Drugs		Indecainide Ranolazine Phenytoin Topiramate Disopyramide Lidocaine Valproic acid Mexiletine Hexylcaine Cinchocaine Mephenytoin Lamotrigine Carbamazepine Moricizine Riluzole Prilocaine Ethotoin Oxcarbazepine Benzonatate Cocaine Quinidine Zonisamide Procainamide Tocainide Promethazine Propafenone Flecainide Encainide Fosphenytoin Quinidine barbiturate Ajmaline Aprindine Dronedarone Brivaracetam Vernakalant Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Isavuconazole Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases		Familial idiopathic ventricular fibrillation Sick sinus syndrome (SSS); Sinus node dysfunction Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Brugada syndrome (BRS) Atrial fibrillation
GWAS		Atrial fibrillation ( 30061737 29892015) Brugada syndrome ( 23872634 32619740) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857 19389651) Electrocardiographic traits ( 32602732 20062063) Global electrical heterogeneity phenotypes ( 29622589) P wave duration ( 28794112 24850809) PR interval ( 29127183 30046033 32439900 20062060 25035420 31217584 23139255 21347284) PR segment ( 24850809) QRS duration ( 27577874 31251759 25035420 31217584 21076409) QT interval ( 29213071 24952745 19305408 19305409 29874175) Resting heart rate ( 27798624) Supraventricular ectopy ( 29618737) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) TPE interval (resting) ( 32386560)	Coronary artery calcification ( 23870195) Response to quetiapine in schizophrenia ( 29503163)
Interacting Genes		23 interacting genes: ANKS1A BANP CALM1 CBL CDK2 CRYAB DLG1 DLG2 DLG3 DLG4 EMC9 NEDD4 NEDD4L PATJ RGS2 RGS3 SNTA1 SNTB1 SNTB2 SNTG2 TEKT4 WWP2 ZMYND19	61 interacting genes: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CEP126 CHD3 CIAO1 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EGFR EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KLK8 LIG1 LRFN1 MARCHF6 METTL18 MON1A MTUS2 NINL NIPSNAP1 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 PRKN RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX
Entrez ID		6331	5997
HPRD ID		02543	02917
Ensembl ID		ENSG00000183873	ENSG00000116741
Uniprot IDs		A0A0A0MT39 E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90	A0A024R939 P41220
PDB IDs		2KBI 2L53 4DCK 4DJC 4JQ0 4OVN 5DBR 6MUD	2AF0 2V4Z 4EKC 4EKD
Enriched GO Terms of Interacting Partners?
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