SCN1B and SCN2B

Data Source:
HPRD (in vivo)

		SCN1B	SCN2B
Description		sodium voltage-gated channel beta subunit 1	sodium voltage-gated channel beta subunit 2
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GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc T-tubule Node Of Ranvier Perikaryon	Voltage-gated Sodium Channel Complex Synapse
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Ion Channel Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential	Voltage-gated Ion Channel Activity Sodium Channel Regulator Activity Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
	Biological Process	Cell Adhesion Axon Guidance Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Corticospinal Neuron Axon Guidance Sodium Ion Transmembrane Transport Locomotion Response To Pyrethroid Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Voltage-gated Sodium Channel Activity Regulation Of Sodium Ion Transmembrane Transporter Activity	Chemical Synaptic Transmission Nervous System Development Sodium Ion Transmembrane Transport Response To Pyrethroid Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		Ranolazine Phenytoin Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil	Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases		Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Brugada syndrome (BRS)
GWAS		Metabolite levels ( 23823483) Serum albumin level ( 23022100)	Preeclampsia ( 23551011)
Interacting Genes		6 interacting genes: ADRA1A ANK3 C5AR2 F2RL1 NFASC SCN2B	1 interacting genes: SCN1B
Entrez ID		6324	6327
HPRD ID		02581	03208
Ensembl ID		ENSG00000105711	ENSG00000149575
Uniprot IDs		A0A1W2PR05 Q07699	O60939 Q5U0K8
PDB IDs		6AGF 6J8G 6J8H 6J8I 6J8J	5FDY 5FEB 6J8E 6J8G 6J8H 6J8I 6J8J 6VRR
Enriched GO Terms of Interacting Partners?
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