SCD and CLEC12B

Data Source:
BioGRID (two hybrid)

		SCD	CLEC12B
Description		stearoyl-CoA desaturase	C-type lectin domain family 12 member B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane	External Side Of Plasma Membrane Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Stearoyl-CoA 9-desaturase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Palmitoyl-CoA 9-desaturase Activity	Protein Phosphatase Binding Carbohydrate Binding Receptor Inhibitor Activity
	Biological Process	Unsaturated Fatty Acid Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Response To Fatty Acid Positive Regulation Of Cold-induced Thermogenesis Monounsaturated Fatty Acid Biosynthetic Process	Natural Killer Cell Inhibitory Signaling Pathway Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Signaling Receptor Activity
Pathways		Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
Drugs
Diseases
GWAS		Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Glycerophospholipid levels ( 26068415) Macular thickness ( 30535121) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 23362303) Vaccenic acid (18:1n-7) levels ( 28298293) White blood cell count (basophil) ( 27863252)	Malaria ( 31844061) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Systolic blood pressure in sickle cell anemia ( 24058526)
Interacting Genes		41 interacting genes: APP AQP6 CD207 CD33 CERS4 CLEC12B CREB3L1 CYB561 CYB5A CYBC1 ERGIC3 GJB1 GPR152 GPR42 GPX8 HSD17B13 JAGN1 KCNJ6 MARCHF5 MCFD2 MFSD14B MGST3 MTIF3 NEDD4L PVR REEP2 RETREG3 RNF5 SCN3B SEC11C SLC10A6 SLC7A14 SPAG4 STOM TIMMDC1 TLCD4 TMEM30B TMPRSS2 TMX2 UBC VMA21	11 interacting genes: IL1RL1 JAGN1 LPAR3 LSMEM2 MALL OPRM1 PLLP PMP22 SCD SEC22A VMA21
Entrez ID		6319	387837
HPRD ID		04941	18266
Ensembl ID		ENSG00000099194	ENSG00000256660
Uniprot IDs		O00767	A0A140VK10 Q2HXU8
PDB IDs		4ZYO
Enriched GO Terms of Interacting Partners?
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