RYR2 and ITPR1

Data Source:
HPRD (in vivo)

		RYR2	ITPR1
Description		ryanodine receptor 2	inositol 1,4,5-trisphosphate receptor type 1
Image			No pdb structure
GO Annotations	Cellular Component	Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Z Disc Cytoplasmic Vesicle Membrane Protein-containing Complex Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma	Nuclear Inner Membrane Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Calcineurin Complex Postsynaptic Density Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse
	Molecular Function	Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-release Channel Activity Enzyme Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding Protein Self-association Suramin Binding Ion Channel Binding Calcium-induced Calcium Release Activity	Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Binding Protein Binding Calcium Ion Transmembrane Transporter Activity Calcium-release Channel Activity Calcium Channel Inhibitor Activity Phosphatidylinositol Binding Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels
	Biological Process	Response To Hypoxia Regulation Of Heart Rate Embryonic Heart Tube Morphogenesis Left Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Hypertrophy Detection Of Calcium Ion Calcium Ion Transport Cellular Calcium Ion Homeostasis Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Muscle Activity Calcium-mediated Signaling Response To Caffeine Ion Transmembrane Transport Calcium-mediated Signaling Using Intracellular Calcium Source Response To Muscle Stretch Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Cytosolic Calcium Ion Concentration Response To Redox State Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Calcium Ion Transport Into Cytosol Sarcoplasmic Reticulum Calcium Ion Transport Cellular Response To Caffeine Cellular Response To Epinephrine Stimulus Establishment Of Protein Localization To Endoplasmic Reticulum Ventricular Cardiac Muscle Cell Action Potential Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Type B Pancreatic Cell Apoptotic Process Positive Regulation Of The Force Of Heart Contraction Regulation Of AV Node Cell Action Potential Regulation Of SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Regulation Of Cardiac Conduction	Response To Hypoxia Calcium Ion Transport Signal Transduction Post-embryonic Development Regulation Of Autophagy Platelet Activation Endoplasmic Reticulum Calcium Ion Homeostasis Epithelial Fluid Transport Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Cardiac Conduction
Pathways		Stimuli-sensing channels Ion homeostasis	PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway cGMP effects Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Flecainide Tetracaine	Caffeine 1D-myo-inositol 1,4,5-trisphosphate Glycerin
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC) Catecholaminergic polymorphic ventricular tachycardia	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Bipolar disorder and eating disorder ( 26433762) Cerivastatin-induced rhabdomyolysis ( 21386754) Exercise treadmill test traits ( 17903301) General risk tolerance (MTAG) ( 30643258) Hippocampal volume ( 31530798) Hypertension ( 17554300) Lipid traits ( 30576415 24386095) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Postoperative stroke after cardiac surgery ( 30678657) PR interval ( 32439900) Response to taxane treatment (docetaxel) ( 23006423) Smoking initiation (ever regular vs never regular) ( 30679032)	Airflow obstruction ( 22837378) Breast cancer ( 23535729) Calcium levels ( 29403010) Diabetic kidney disease ( 26305897) Gamma glutamyl transferase levels ( 29403010) Hand grip strength ( 29691431) Hematocrit ( 32888494) Lead levels ( 26025379) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Systolic blood pressure ( 26969751) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels ( 32203549 32154731) Uterine fibroids ( 30194396) Weight ( 28552196) Western dietary pattern ( 28644415)
Interacting Genes		16 interacting genes: AKAP6 ALB CACNA1C FKBP1B HOMER1 HSPB2 ITPR1 LINC00839 MDM2 PRKACA PRKAR2A PSEN1 RYR1 RYR3 SMAD5 SRI	32 interacting genes: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 BECN1 BRCA1 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERBB2 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 IRAG1 ITPR3 ITPRIP LYN PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4
Entrez ID		6262	3708
HPRD ID		01619	00925
Ensembl ID		ENSG00000198626	ENSG00000150995
Uniprot IDs		Q92736	A0A3B3ITU8 A0A3F2YNW8 B4DER3 B4DGH1 Q14643 Q59H91
PDB IDs		4JKQ 6Y4O 6Y4P
Enriched GO Terms of Interacting Partners?
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