RRAS and RAP1GDS1

Data Source:
BioGRID (two hybrid)

		RRAS	RAP1GDS1
Description		RAS related	Rap1 GTPase-GDP dissociation stimulator 1
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Extracellular Exosome	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein-containing Complex Binding	GTPase Activator Activity Protein Binding
	Biological Process	Leukocyte Differentiation Ras Protein Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Angiogenesis Regulation Of Protein Kinase B Signaling Face Morphogenesis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration
Pathways		SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Pulse pressure ( 27618447) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27618447)	Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377)
Interacting Genes		18 interacting genes: ACY3 AFDN ARAF BCL2 EEF1A1 EPHB2 MRPL36 NAV2 NCK1 PPP2CA RAF1 RALGDS RAP1GDS1 RASIP1 RASSF5 SOS1 TRIM55 TRIM63	23 interacting genes: CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS MBIP NRAS PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451
Entrez ID		6237	5910
HPRD ID		01299	11763
Ensembl ID		ENSG00000126458	ENSG00000138698
Uniprot IDs		A0A024QZF2 P10301	B3KNU0 P52306 Q6U7G8
PDB IDs		2FN4	5XGC 5ZHX
Enriched GO Terms of Interacting Partners?
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