RPS6KB1 and IRS1

  • Data Source:
  • BioGRID (enzymatic study)

RPS6KB1

IRS1

Description ribosomal protein S6 kinase B1 insulin receptor substrate 1
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GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • C-reactive protein levels ( 30388399)
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Chronic lymphocytic leukemia or multiple sclerosis ( 31407831)
  • Crohn's disease ( 28067908)
  • Inflammatory bowel disease ( 23128233)
  • Multiple sclerosis ( 21833088)
  • Obesity-related traits ( 23251661)
  • Triglycerides ( 30275531)
Interacting Genes 60 interacting genes: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B DEPTOR DPPA4 EEF2K EIF3B EIF3F EIF4B EIF4EBP1 EP300 FBXO7 GDI2P1 GRIA1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 PIP4K2A POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RPS6 RPTOR SRC STK11 SYK TBK1 TERT TRAF4 URI1 USP11 XPO1 79 interacting genes: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK3 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 NUMB PASK PDPK1 PELI1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRD PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SHC1 SIK2 SOCS1 SOCS3 TRIM72 TUB TYK2 UBC UBTF YWHAB YWHAE YWHAG YWHAZ
Entrez ID 6198 3667
HPRD ID 10202 00943
Ensembl ID ENSG00000108443 ENSG00000169047
Uniprot IDs P23443 P35568
PDB IDs 3A60 3A61 3A62 3WE4 3WF5 3WF6 3WF7 3WF8 3WF9 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46 4RLO 4RLP 5WBH 5WBK 1IRS 1K3A 1QQG 2Z8C 5U1M 6BNT
Enriched GO Terms of Interacting Partners?
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