RPS6KA1 and LNX1

Data Source:
BioGRID (unspecified method)

		RPS6KA1	LNX1
Description		ribosomal protein S6 kinase A1	ligand of numb-protein X 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Serine Kinase Activity Protein Threonine Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding PDZ Domain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Apoptotic Process Cell Cycle Signal Transduction Peptidyl-serine Phosphorylation Positive Regulation Of Cell Growth Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways		ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Purvalanol A Fostamatinib
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Fasting plasma glucose ( 31932636) Glucose homeostasis traits ( 25524916) Lymphocyte counts ( 32888494) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Rosacea symptom severity ( 29771307) Triglyceride levels ( 30108155) White blood cell count ( 32888494)	Beard thickness ( 26926045) Cervical artery dissection ( 25420145) DNA methylation (variation) ( 23725790) Heel bone mineral density ( 30598549) Height ( 28552196) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Uterine fibroids ( 30194396 31649266)
Interacting Genes		86 interacting genes: ARHGEF11 ARHGEF12 ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DEPTOR DLC1 DLG4 EEF1D EEF2K ERBIN ESR1 ETV1 FGFR1 FOS GBP2 GMFB GOPC GORASP1 GORASP2 GRB2 GRID2IP GSK3B HTRA1 L1CAM LIMK2 LNX1 MAGI1 MAGI2 MAGI3 MAPK1 MAPK3 MAPT MAST1 MAST2 METTL1 MITF MPP1 MTOR MXD1 NFKBIA NR4A1 NR4A2 NR4A3 PARD3B PDCD4 PDPK1 PDZD7 PDZK1 PDZRN3 PDZRN4 PHAX POLDIP3 PPM1G PPP1R3A PPP1R9A PTPN3 RPTOR SHANK3 SHROOM2 SLC9A3R2 SNTA1 SNTB1 SNTG2 SNX27 SRF SRSF5 SYK SYNJ2BP TAMALIN TOB2 TP53 TSC2 TTK UBE2T VCP WHRN YBX1 YWHAB	474 interacting genes: ABCA1 ABCB1 ABI2 ABR ACAT2 ACTN1 ACTN3 ACTN4 ACY3 ADAMTSL4 ADRA1D AGTRAP AIDA AIMP2 AKIRIN2 ALDOC ALKBH3 AMMECR1L ANKS1A AP1M1 APIP APOL4 APP ARF3 ARFIP2 ARHGAP6 ARHGEF16 ARVCF ATPAF2 ATRIP AURKB AURKC AXIN2 BCR BEND7 BICD2 BIRC2 BLVRA BLZF1 BORCS6 BPIFA1 BTBD1 C10orf88 C1QTNF1 CA8 CABP5 CADPS CALCOCO2 CAMK2N2 CARD9 CASP6 CATSPERD CBX1 CBY1 CBY2 CCBE1 CCDC102B CCDC33 CCDC85B CCDC88B CCDC91 CCNDBP1 CDA CDC42EP4 CDIPT CDKN2D CEP70 CEP72 CEP76 CEP85 CGN CIB3 CIRBP CITED1 CLDN1 CLDN17 CLDN2 CLK1 CLK2 CLK3 CMTM5 COIL CPNE2 CPSF7 CRACR2B CRX CTBP1 CTNND2 CTSO CUTC CXADR CYSLTR2 CYSRT1 DAB1 DAPK1 DCTD DCTPP1 DCUN1D5 DDIT3 DDX17 DENND1B DEPTOR DERL1 DEUP1 DHPS DMC1 DNPEP DOCK9 DPF2 DRAP1 DRG1 DTX2 DUSP29 DVL3 DYDC1 DYNLT1 EBF4 EDC3 EEF2KMT EFEMP2 EFHC2 EGLN3 EHMT2 EIF1AD EIF4A3 EIF4H ENOX1 ENOX2 EPHB3 EPM2AIP1 EVI5L EXOC8 EXOSC1 EXOSC4 EXOSC8 FAM118A FAM124A FAM90A1 FAM9B FASN FBP1 FBXL12 FHL3 FOXP2 FSD2 FXR1 GAS2L2 GDI1 GIPR GJD2 GJD4 GLRX3 GMCL1 GMNN GOLPH3L GPKOW GPR142 GRAP2 GRB2 GRIN1 GRIPAP1 GUCD1 HDX HEXIM2 HIP1 HMBOX1 HMG20A HNRNPF HNRNPH1 HOMER3 HOMEZ HOOK2 HOXA1 HSBP1 HSF2BP HTR2B HUNK IGSF5 IHO1 IKZF3 IL16 IL3RA ILF3 INKA2 INO80E INSC IP6K3 ISCU JAK3 JOSD1 KALRN KATNAL2 KCNA4 KCTD1 KCTD13 KCTD17 KCTD6 KCTD7 KCTD9 KHDRBS2 KHDRBS3 KIAA1328 KIF24 KIFC3 KLHL12 KPRP KRT15 KRT16 KRTAP1-1 KRTAP10-8 KRTAP12-3 KRTAP13-3 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 KXD1 LCLAT1 LCP2 LDB2 LDOC1 LEPROTL1 LGALS14 LGR6 LHX2 LNX2 LONRF1 LRRC3B LRRC73 LSM2 LUZP4 LZTS1 MAD1L1 MAGEA11 MAGEB18 MAPK9 MAPRE2 MEMO1 MEOX2 METTL21A MID2 MLX MRFAP1L1 MRPS24 MRPS6 MSANTD4 MSC MTMR9 MTUS2 MUSTN1 MVB12B MYEF2 NAB2 NADK NAGK NBPF19 NCK2 NDC80 NDOR1 NDUFAB1 NECAB1 NECAB2 NEK6 NKD2 NME1 NME7 NOTCH2NLA NRCAM NUDT14 NUMB NUP37 NUP62 NXT2 ODAD1 ORMDL1 ORMDL3 OSBP2 OSBPL3 OSGIN1 PAFAH1B3 PAICS PAK5 PBK PBLD PCBD1 PDE3B PDZRN3 PDZRN4 PFDN5 PKDREJ PKM PKP4 PLEKHA2 PNMA1 PNMA3 PNMA5 PNMT POMGNT1 POU6F2 PPIA PPID PPIH PPP1R13B PQBP1 PRDM14 PRKAR1B PRKRA PRMT5 PRPH PRR13 PRTFDC1 PSMC1 PSME2 PSME3 PSMF1 PTGIR PTPN11 PTS PURB QARS1 RAB33A RABAC1 RABIF RAD51D RAD54B RALY RASL11B RBAK RBCK1 RBM20 RBMX RBMY1A1 RBMY1F RBMY1J REEP6 RFPL3 RGS20 RIOX2 ROBO3 ROPN1 RPIA RPS6KA1 RUFY4 RUNDC3A RUVBL2 S100A3 S100B SAPCD1 SAT1 SCLT1 SCML1 SCML2 SCNM1 SDK1 SEPTIN1 SGF29 SH2D2A SHFL SHTN1 SLC6A15 SLC6A5 SNCB SNRNP25 SNRPA SNRPF SOCS6 SP4 SPG21 SPHKAP SRSF1 SRSF3 SSNA1 SSTR3 STAC2 STRN STX5 SUV39H1 SUV39H2 SYCE1L SYTL2 TACO1 TAX1BP1 TBC1D1 TBCEL TCF12 TCL1A TDO2 TEKT4 TGM7 THAP1 THAP7 THG1L TIFA TMEM14C TMEM239 TNFAIP1 TNFAIP3 TNFRSF18 TPM4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM10 TRIM14 TRIM21 TRIM23 TRIM27 TRIM3 TRIM39 TRIM42 TRIM50 TRIM54 TRIM60 TRIM68 TRIM8 TRIP13 TRIP6 TRMT12 TSC2 TSC22D4 TSG101 TSN TSPYL2 TSSK3 TYRO3 UBASH3A UBE2D2 UBE2D4 UBE2N UBE2V2 UBP1 ULK2 UPP2 USP54 VASN VCP VMAC VPS37B VPS52 VRK2 WAC WDR25 WNT8A WWP1 YWHAZ ZADH2 ZBED1 ZBTB2 ZBTB24 ZBTB26 ZBTB43 ZBTB8A ZCCHC10 ZFP64 ZGPAT ZNF148 ZNF213 ZNF263 ZNF346 ZNF426 ZNF446 ZNF552 ZNF581 ZNF593 ZNF655 ZRANB1
Entrez ID		6195	84708
HPRD ID		03402	17287
Ensembl ID		ENSG00000117676	ENSG00000072201
Uniprot IDs		Q15418	Q8TBB1
PDB IDs		2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62 6TWY	3B76 5H7R 5H7S
Enriched GO Terms of Interacting Partners?
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