MRPL12 and POLR1D

Data Source:
BioGRID (two hybrid)

		MRPL12	POLR1D
Description		mitochondrial ribosomal protein L12	RNA polymerase I and III subunit D
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit	RNA Polymerase III Complex RNA Polymerase I Complex
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein Dimerization Activity
	Biological Process	Mitochondrial Transcription Positive Regulation Of Transcription, DNA-templated Mitochondrial Translational Elongation Mitochondrial Translational Termination	Transcription, DNA-templated
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination	Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases			Treacher Collins syndrome
GWAS		LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Refractive error ( 32231278) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Body mass index ( 26426971)
Interacting Genes		24 interacting genes: CBX3 COX6A2 EFCAB2 EFEMP2 EXOC3L2 FBLN1 KRTAP10-1 MAPRE3 MICOS10-NBL1 MORF4L1 MORF4L2 NBL1 NTAQ1 NTM OLIG1 POLR1D PPP1R16A RARG SAT1 SEPTIN1 TMEM51 TRIM59 TXNDC9 ZNF76	15 interacting genes: CDC25A CRKL DDIT3 DNAJB4 DNAJB6 E2F4 GRB2 HAX1 MAGEA11 MRPL12 NFKBIB NR3C1 POLR1C POLR1G PXN
Entrez ID		6182	51082
HPRD ID		03849	17877
Ensembl ID		ENSG00000262814	ENSG00000186184
Uniprot IDs		P52815	A0A087WTY1 P0DPB5 P0DPB6
PDB IDs		6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG
Enriched GO Terms of Interacting Partners?
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