RIC8A and ATP1A4

Data Source:
BioGRID (two hybrid)

		RIC8A	ATP1A4
Description		RIC8 guanine nucleotide exchange factor A	ATPase Na+/K+ transporting subunit alpha 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Raft Sperm Midpiece Photoreceptor Cell Cilium Rod Photoreceptor Outer Segment
	Molecular Function	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	P-type Sodium:potassium-exchanging ATPase Activity Protein Binding ATP Binding ATPase-coupled Cation Transmembrane Transporter Activity Kinase Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Vasculature Development G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Visual Learning Cell Migration Involved In Gastrulation Positive Regulation Of GTPase Activity Cell-cell Adhesion Involved In Gastrulation Basement Membrane Organization	Ion Transport Potassium Ion Transport Sodium Ion Transport Cellular Sodium Ion Homeostasis Cell Surface Receptor Signaling Pathway Spermatogenesis Fertilization Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Cellular Potassium Ion Homeostasis Flagellated Sperm Motility Regulation Of Cellular PH Ion Transmembrane Transport Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Regulation Of Membrane Potential Potassium Ion Transmembrane Transport Transport Across Blood-brain Barrier Proton Transmembrane Transport Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane
Pathways			Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs
Diseases
GWAS		Cataracts (operation) ( 31816047) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Mean corpuscular hemoglobin concentration ( 29403010) Meningioma ( 29762745) Platelet count ( 24026423) Uterine fibroids ( 21460842 31488892 31649266) Uterine fibroids (MTAG) ( 31488892)	Composite immunoglobulin trait (IgA/IgG) ( 28628107) Gout ( 22179738)
Interacting Genes		24 interacting genes: ATP1A4 EFEMP1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS MAPK8IP3 NECAB2 NUTM1 PACSIN2 RABAC1 SDCBP SH3GLB1 SLC2A13 TERF1 TUBB2A UBQLN1 UBQLN4 XPO1 ZDHHC17 ZNF585B	3 interacting genes: CTAG1A CTAG1B RIC8A
Entrez ID		60626	480
HPRD ID		12373	09541
Ensembl ID		ENSG00000177963	ENSG00000132681
Uniprot IDs		Q9NPQ8	Q13733
PDB IDs
Enriched GO Terms of Interacting Partners?
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