ALX4 and ALX1

Data Source:
HPRD (in vitro)

		ALX4	ALX1
Description		ALX homeobox 4	ALX homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Golgi Apparatus Nuclear Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Skeletal System Development Hair Follicle Development Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Embryonic Skeletal System Morphogenesis Roof Of Mouth Development	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis
Pathways
Drugs
Diseases		Frontonasal dysplasia Enlarged parietal foramina/cranium bifidum	Frontonasal dysplasia
GWAS		Blood pressure measurement (high sodium intervention) ( 24165912) Brain morphology (MOSTest) ( 32665545) Cadmium levels ( 26025379) Excessive hairiness ( 29895819) Gout ( 22179738) Male-pattern baldness ( 29146897 27182965) Monobrow ( 27182965) Response to antidepressants in depression ( 29998114) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Nonsyndromic cleft lip ( 31609978) Nose size ( 27182965)
Interacting Genes		14 interacting genes: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 IQUB LEF1 PARVG SOX10 SOX2	17 interacting genes: ALX4 APCS CLIC3 CREBBP EEF1D EP300 GRP IPO13 KAT5 KRTAP4-4 OR52L1 PACRGL RARA RBM45 SRA1 UROC1 ZNF300
Entrez ID		60529	8092
HPRD ID		05661	03316
Ensembl ID		ENSG00000052850	ENSG00000180318
Uniprot IDs		Q9H161	Q15699 V9HWA7
PDB IDs		2M0C
Enriched GO Terms of Interacting Partners?
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