SAV1 and STK4

Data Source:
HPRD (in vitro, in vivo)

		SAV1	STK4
Description		salvador family WW domain containing protein 1	serine/threonine kinase 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Dendrite	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Protein Binding Signaling Receptor Complex Adaptor Activity Beta-1 Adrenergic Receptor Binding Identical Protein Binding SMAD Binding Type II Activin Receptor Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Hair Follicle Development Apoptotic Process Signal Transduction Keratinocyte Differentiation Hippo Signaling Positive Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Regulation Of Stem Cell Population Maintenance	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Population Proliferation Peptidyl-serine Phosphorylation Keratinocyte Differentiation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Binding Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Protein Stabilization Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways		Signaling by Hippo	Signaling by Hippo
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 32888494 27863252) Periodontal disease-related phenotype (Socransky) ( 24347629) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494) Platelet distribution width ( 32888494) Refractive error ( 32231278)	Bipolar disorder ( 31043756) Mean platelet volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		5 interacting genes: EP300 NEDD4 RASSF1 STK3 STK4	23 interacting genes: AKT1 CASP3 CNKSR1 CSN1S1 DAXX DDIT4L H2BC21 IL2RG KEAP1 LATS1 MARK2 MBP NEDD4 PICK1 RASSF1 RASSF5 RNF31 SAV1 SGMS1 SIRT1 STK3 THAP12 TP53
Entrez ID		60485	6789
HPRD ID		06229	05395
Ensembl ID		ENSG00000151748	ENSG00000101109
Uniprot IDs		B3KTQ1 Q9H4B6	Q13043
PDB IDs		6AO5	2JO8 3COM 4NR2 4OH8 5TWG 5TWH 6YAT
Enriched GO Terms of Interacting Partners?
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