RING1 and ELAC2

Data Source:
HPRD (two hybrid)

		RING1	ELAC2
Description		ring finger protein 1	elaC ribonuclease Z 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Sex Chromatin Nucleus Nucleoplasm Cytosol Nuclear Speck PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid
	Molecular Function	Chromatin Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activator Activity	RNA Binding TRNA-specific Ribonuclease Activity 3'-tRNA Processing Endoribonuclease Activity Metal Ion Binding
	Biological Process	Anterior/posterior Pattern Specification Histone H2A Monoubiquitination Negative Regulation Of Transcription, DNA-templated Camera-type Eye Morphogenesis Regulation Of Catalytic Activity Negative Regulation Of G0 To G1 Transition	TRNA 3'-end Processing Mitochondrial TRNA 3'-trailer Cleavage, Endonucleolytic Mitochondrial TRNA Processing
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	tRNA processing in the nucleus tRNA processing in the mitochondrion rRNA processing in the mitochondrion
Drugs
Diseases
GWAS		Asthma ( 32296059) Wegener's granulomatosis ( 23740775)	Squamous cell lung carcinoma ( 28604730)
Interacting Genes		34 interacting genes: APP BMI1 CBX4 CBX7 CBX8 E2F6 ELAC2 ERG FBXO38 FHL1 H3-4 NFKBID PCGF2 PCGF3 PCGF5 PCGF6 PHC1 PIK3R3 PTEN RB1 RNF2 RYBP TP53 TRIM55 TRIM63 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K YAF2 ZIM3	9 interacting genes: ASCC2 CTBP1 CTBP2 CUX1 GOLM1 NDUFA7 RING1 SMAD2 SUMO2
Entrez ID		6015	60528
HPRD ID		03624	05641
Ensembl ID		ENSG00000204227	ENSG00000006744
Uniprot IDs		A0A1U9X8F2 Q06587	A0A0S2Z5M8 Q9BQ52
PDB IDs
Enriched GO Terms of Interacting Partners?
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