RHAG and ICAM4

Data Source:
HPRD (in vivo)

		RHAG	ICAM4
Description		Rh associated glycoprotein	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Ammonium Transmembrane Transporter Activity Leak Channel Activity Ankyrin Binding Carbon Dioxide Transmembrane Transporter Activity	Integrin Binding
	Biological Process	Cellular Ion Homeostasis Carbon Dioxide Transport Ammonium Transport Bicarbonate Transport Carbon Dioxide Transmembrane Transport Ammonium Transmembrane Transport Inorganic Cation Transmembrane Transport	Cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response Cell-cell Adhesion
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Rhesus glycoproteins mediate ammonium transport. Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions
Drugs
Diseases		Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)
GWAS		Alcohol dependence ( 26365420) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Blood protein levels ( 30072576 28240269)
Interacting Genes		11 interacting genes: ANK1 CD47 CREB3L3 ERGIC3 FAM209A GYPB ICAM4 LMNA SLC4A1 TEX29 UNC93A	13 interacting genes: CREB3 CYSRT1 ITGA4 ITGAM ITGAV ITGB1 ITGB2 KRT31 KRT34 MTUS2 NBPF19 NOTCH2NLA RHAG
Entrez ID		6005	3386
HPRD ID		01582	00198
Ensembl ID		ENSG00000112077	ENSG00000105371
Uniprot IDs		Q02094 Q96E98	Q14773 U5U6P8
PDB IDs
Enriched GO Terms of Interacting Partners?
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