RGS4 and KRIT1

Data Source:
BioGRID (pull down, unspecified method)

		RGS4	KRIT1
Description		regulator of G protein signaling 4	KRIT1 ankyrin repeat containing
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Protein-containing Complex	Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding GTPase Regulator Activity
	Biological Process	Inactivation Of MAPK Activity Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Heart Rate Response To Cocaine Response To Morphine Positive Regulation Of GTPase Activity Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Small GTPase Mediated Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Cell Redox Homeostasis Regulation Of Catalytic Activity Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs
Diseases			Cerebral cavernous malformation
GWAS		Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)	Coffee consumption ( 31046077) Hippocampal volume in Alzheimer's disease dementia ( 29274321)
Interacting Genes		13 interacting genes: CALM1 COPB1 COPB2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KRIT1 PLCB1 PTAFR	7 interacting genes: FAS ITGB1BP1 PLCB3 RAP1A RGS4 TRPV4 UBE2K
Entrez ID		5999	889
HPRD ID		03947	05020
Ensembl ID		ENSG00000117152	ENSG00000001631
Uniprot IDs		A0A024R909 P49798	A4D1F7 O00522
PDB IDs			3U7D 4DX8 4DXA 4HDO 4HDQ 4JIF 4TKN 5D68 6OQ3 6OQ4
Enriched GO Terms of Interacting Partners?
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