RGS4 and MPZ

Data Source:
BioGRID (proximity labelling technology)

		RGS4	MPZ
Description		regulator of G protein signaling 4	myelin protein zero
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Protein-containing Complex	Plasma Membrane Integral Component Of Plasma Membrane Myelin Sheath Synapse
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding	Structural Molecule Activity
	Biological Process	Inactivation Of MAPK Activity Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Heart Rate Response To Cocaine Response To Morphine Positive Regulation Of GTPase Activity Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential	Chemical Synaptic Transmission Myelination Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Aggregation
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)	Hip circumference adjusted for BMI ( 28552196) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		13 interacting genes: CALM1 COPB1 COPB2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KRIT1 PLCB1 PTAFR	3 interacting genes: PINX1 PMP22 PSMB3
Entrez ID		5999	4359
HPRD ID		03947	01159
Ensembl ID		ENSG00000117152	ENSG00000158887
Uniprot IDs		A0A024R909 P49798	A0A5F9ZI26 P25189
PDB IDs			1N2P 3OAI
Enriched GO Terms of Interacting Partners?
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