RFC3 and CHTF8

Data Source:
HPRD (in vivo)

		RFC3	CHTF8
Description		replication factor C subunit 3	chromosome transmission fidelity factor 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Ctf18 RFC-like Complex	Nucleus Ctf18 RFC-like Complex
	Molecular Function	DNA Binding DNA Clamp Loader Activity Protein Binding ATPase Activity Single-stranded DNA Helicase Activity	DNA Clamp Loader Activity Single-stranded DNA Helicase Activity
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding Nucleotide-excision Repair, DNA Incision Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Response To Organophosphorus Error-free Translesion Synthesis Positive Regulation Of DNA-directed DNA Polymerase Activity Regulation Of Signal Transduction By P53 Class Mediator	DNA Replication Mitotic Sister Chromatid Cohesion DNA Duplex Unwinding Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint	Polymerase switching on the C-strand of the telomere
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627) Colorectal cancer or advanced adenoma ( 30510241) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Obesity-related traits ( 23251661)	Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		13 interacting genes: ANKRD40 ARFGAP1 CHTF8 INCA1 KHDRBS2 KHDRBS3 MESD PCNA PICK1 PTEN RAD17 RFC1 RFC4	6 interacting genes: AP4M1 DSCC1 EIF4EBP1 PCNA RFC3 WBP4
Entrez ID		5983	54921
HPRD ID		02676	16797
Ensembl ID		ENSG00000133119	ENSG00000168802
Uniprot IDs		A0A024RDQ8 P40938	P0CG13
PDB IDs		6VVO
Enriched GO Terms of Interacting Partners?
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