BCL2L1 and BID

Data Source:
BioGRID (imaging technique)
HPRD (two hybrid)

		BCL2L1	BID
Description		BCL2 like 1	BH3 interacting domain death agonist
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Centrosome Cytosol Integral Component Of Membrane Synaptic Vesicle Membrane Nuclear Membrane Bcl-2 Family Protein Complex	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Mitochondrial Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding	Death Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Endocytosis Mitotic Cell Cycle Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Suppression By Virus Of Host Apoptotic Process Cytokine-mediated Signaling Pathway Regulation Of Cytokinesis Response To Cytokine Negative Regulation Of Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Defense Response To Virus Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Mitochondrial Changes Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein-containing Complex Assembly Regulation Of Cell Population Proliferation Signal Transduction In Response To DNA Damage Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Neuron Apoptotic Process Protein-containing Complex Assembly Establishment Of Protein Localization To Membrane Positive Regulation Of Release Of Cytochrome C From Mitochondria Hepatocyte Apoptotic Process Mitochondrial Outer Membrane Permeabilization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome RAS processing STAT5 activation downstream of FLT3 ITD mutants	Activation of BAD and translocation to mitochondria Activation and oligomerization of BAK protein BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation, translocation and oligomerization of BAX TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation, myristolyation of BID and translocation to mitochondria
Drugs		4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID Isosorbide Gossypol
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Monocyte percentage of white cells ( 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Prudent dietary pattern ( 28644415) Putamen volume ( 29147026) Subcortical brain region volumes ( 25607358)	Adult body size ( 32376654) Diisocyanate-induced asthma ( 25918132) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		110 interacting genes: ACTB AKT1 ANTXR1 APAF1 AURKA AVEN BAD BAG1 BAK1 BAX BBC3 BCAP31 BCL2 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BID BIK BLK BMF BNIP1 BNIP3 BNIP3L BNIP5 BNIPL C10orf67 CAPN1 CASP1 CASP8 CASP9 CDKN2A CFLAR CHEK1 CREB3 CRYAA CRYAB CYCS DOCK7 EDRF1 ELOVL4 ERGIC3 FBP1 FKBP8 G0S2 GLOD4 GNLY GOLM1 GORAB GSK3A GSK3B HNRNPA1 HRK IKZF3 IRS1 IRS2 LARP1 MAPK14 MAPK8 MAPK9 MAPKAPK2 MCL1 METTL23 MOAP1 MTIF3 MTNR1B MTOR NLRP1 PARK7 PDIA4 PLD3 PLK1 PLK3 PMAIP1 PPHLN1 PPP1CA PRKN PSEN1 PSEN2 PTN RAD9A RAF1 RBM5 REEP4 RHBDD2 RIC3 RNF183 RNF4 RTN1 RTN4 RYR3 SIVA1 SNCA SPNS1 TLE1 TMBIM6 TMEM50B TP53 TP53BP2 TPT1 UBE2I UBR1 UHRF2 VAC14 VDAC1 ZFYVE1 ZHX1 ZNF219	37 interacting genes: AHCYL1 BAK1 BAX BCL2 BCL2A1 BCL2L1 BCL2L2 CAPN1 CAPN2 CASP1 CASP10 CASP2 CASP3 CASP8 CRMP1 CRNKL1 CSNK1A1 CSNK1E CSNK2A1 CSNK2A2 CSNK2B DDIT4L ERG28 FBN3 GAPDH GBP2 GZMB MCL1 PLEKHM1 RBM48 REL RPA1 SETDB1 TLE1 TUBB2B YWHAB ZHX1
Entrez ID		598	637
HPRD ID		02497	03590
Ensembl ID		ENSG00000171552	ENSG00000015475
Uniprot IDs		A0A0S2Z3C5 Q07817 Q5TE63	A8ASI8 B2ZP79 B3KT21 P55957
PDB IDs		1BXL 1G5J 1LXL 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 1YSG 1YSI 1YSN 2B48 2LP8 2LPC 2M03 2M04 2ME8 2ME9 2MEJ 2O1Y 2O2M 2O2N 2P1L 2PON 2YJ1 2YQ6 2YQ7 2YXJ 3CVA 3FDL 3FDM 3INQ 3IO8 3PL7 3QKD 3R85 3SP7 3SPF 3WIZ 3ZK6 3ZLN 3ZLO 3ZLR 4A1U 4A1W 4AQ3 4BPK 4C52 4C5D 4CIN 4EHR 4HNJ 4IEH 4PPI 4QVE 4QVF 4QVX 4TUH 4Z9V 5AGW 5AGX 5B1Z 5C3G 5FMJ 5FMK 5VAY 5VX3 6BF2 6DCN 6DCO 6F46 6HJL 6IJQ 6O0K 6O0L 6O0M 6O0O 6O0P 6RNU 6ST2 6VWC 6X7I 6ZHC 7CA4	1ZY3 2BID 2KBW 2M5B 2M5I 4BD2 4QVE 4ZEQ 4ZIG 4ZII 5AJJ 5C3F
Enriched GO Terms of Interacting Partners?
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