RBBP5 and KMT2A

Data Source:
BioGRID (pull down, affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		RBBP5	KMT2A
Description		RB binding protein 5, histone lysine methyltransferase complex subunit	lysine methyltransferase 2A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex MLL1 Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Methylated Histone Binding Histone Methyltransferase Activity (H3-K4 Specific)	Minor Groove Of Adenine-thymine-rich DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Identical Protein Binding Protein Homodimerization Activity Unmethylated CpG Binding Lysine-acetylated Histone Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Response To Estrogen Post-translational Protein Modification Regulation Of Megakaryocyte Differentiation Histone H3-K4 Methylation Beta-catenin-TCF Complex Assembly	Apoptotic Process Positive Regulation Of Transporter Activity Circadian Regulation Of Gene Expression Embryonic Hemopoiesis Histone H4-K16 Acetylation Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Protein-containing Complex Assembly Regulation Of Histone H3-K14 Acetylation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of DNA Methylation Regulation Of Histone H3-K9 Acetylation
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Mean platelet volume ( 24026423 32888494) Meat-related diet ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		13 interacting genes: ASH2L CHD8 CTBP1 CTNNB1 H3-4 H3C14 KMT2A KMT2B MEN1 PTEN RB1 UBE2I WDR5	31 interacting genes: ASH2L AVP BMI1 CBX4 CREBBP CTNNB1 FASLG H3-3A H3-4 H3C1 H3C14 HCFC1 HCFC2 INS KAT8 MEN1 MTM1 OXT PAF1 PLXNB1 PPIE PPP1R15A RBBP5 RNF2 SBF1 SET SVIL TAF9 TASP1 TOP1 WDR5
Entrez ID		5929	4297
HPRD ID		02826	01162
Ensembl ID		ENSG00000117222	ENSG00000118058
Uniprot IDs		A0A024R9B5 B4DLF8 Q15291	Q03164
PDB IDs		3P4F 4X8N 4X8P 5F6K 5F6L 6KIU 6KIV 6KIW 6KIX 6KIZ 6KM7 6PWV 6PWW 6PWX 7BRE	2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2MSR 2MTN 2W5Y 2W5Z 3EG6 3EMH 3LQH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6 4NW3 5F5E 5F6L 5SVH 6EMQ 6KIU 6KIV 6KIX 6KIZ 6PWV 6PWW 6U9K 6U9M 6U9N 6U9R
Enriched GO Terms of Interacting Partners?
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