RARA and PHF8

Data Source:
BioGRID (fluorescent resonance energy transfer)

		RARA	PHF8
Description		retinoic acid receptor alpha	PHD finger protein 8
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cell Surface Actin Cytoskeleton Protein-containing Complex	Nucleus Nucleoplasm Nucleolus Nuclear Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Retinoic Acid Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Signaling Receptor Binding Protein Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Chromatin DNA Binding Protein Kinase B Binding Retinoic Acid-responsive Element Binding Protein Kinase A Binding Alpha-actinin Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Transcription Coregulator Activity Iron Ion Binding Protein Binding Zinc Ion Binding 2-oxoglutarate-dependent Dioxygenase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-K9 Specific) Methylated Histone Binding Histone Demethylase Activity (H4-K20 Specific) Histone Demethylase Activity (H3-K36 Specific) Histone Demethylase Activity (H3-K27 Specific)
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Positive Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Cell Differentiation Negative Regulation Of Granulocyte Differentiation Response To Retinoic Acid Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Apoptotic Cell Clearance Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Binding Cellular Response To Estrogen Stimulus	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Protein Demethylation Brain Development Histone H3-K9 Demethylation Histone H4-K20 Demethylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Ribosomal DNA Heterochromatin Assembly Histone H3-K36 Demethylation Histone H3-K27 Demethylation
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis	HDMs demethylate histones
Drugs		Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Isotretinoin Tamibarotene LGD-1550 Trifarotene
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Acute myeloid leukemia (AML)	Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Asthma ( 31619474)	Bipolar disorder and schizophrenia ( 21057379)
Interacting Genes		97 interacting genes: ACTN4 AKT1 ALOX15B ALX1 ARID1A ARID5A ARNTL BAG1 BBS4 BTG1 CCND3 CCNDBP1 CDK7 CEBPA CLOCK CNOT1 COPS2 E2F1 ESR1 FGFR1 FN1 FOXO1 GADD45G GATA2 HDAC1 HDAC3 HDAC4 HMGA1 HR IRX4 ITGB1BP2 KAT2B KDM5A KLF5 LRIF1 MAPK6 MCRS1 MDM2 MECR MED1 MED25 MED6 MMS19 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR2C1 NR2E3 NR3C1 NRBF2 NRIP1 NRIP2 NSD1 PARP1 PHF8 PIN1 PLEKHF2 PML PNRC2 POU2F1 PPARG PRAME PRDX6 PRKCA PSMC5 RXRA RXRB RXRG S100A3 SIRT1 SMARCD3 SNW1 SP1 SPEN SRC SRF STAT5B TADA3 TEKT4 THRB TNIP1 TOP2B TRIB3 TRIM24 TRIP4 UBE3A UBQLN1 USP7 ZBTB16	8 interacting genes: APP H3-4 H3C1 H4C1 POLR2A RARA SUMO2 USP7
Entrez ID		5914	23133
HPRD ID		06769	06599
Ensembl ID		ENSG00000131759	ENSG00000172943
Uniprot IDs		A8K840 A8MUP8 F1D8N9 P10276 Q6I9R7	O95327 Q9UPP1
PDB IDs		1DKF 1DSZ 3A9E 3KMR 3KMZ 4DQM 5K13 6XWG	2WWU 3K3N 3K3O 3KV4 4DO0
Enriched GO Terms of Interacting Partners?
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