RAD9A and CLSPN

Data Source:
HPRD (in vivo, in vitro)

		RAD9A	CLSPN
Description		RAD9 checkpoint clamp component A	claspin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Checkpoint Clamp Complex	Nucleus Nucleoplasm Golgi Apparatus
	Molecular Function	Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding	DNA Secondary Structure Binding Protein Binding Anaphase-promoting Complex Binding
	Biological Process	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Intra-S DNA Damage Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Mitotic G2 DNA Damage Checkpoint Protein Deubiquitination Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Apoptotic cleavage of cellular proteins Activation of ATR in response to replication stress Ub-specific processing proteases Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		38 interacting genes: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CAD CHEK2 CLSPN COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEM1B FEN1 HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 OGG1 PCNA POLB PRKCE RAD17 RAD9B RHNO1 RPA1 RPA2 SF3B3 TDG TLK1 TOPBP1 WRN	11 interacting genes: ATR BRCA1 CASP7 CDC7 CHEK1 FZR1 RAD9A USP20 USP28 USP29 USP7
Entrez ID		5883	63967
HPRD ID		04788	09257
Ensembl ID		ENSG00000172613	ENSG00000092853
Uniprot IDs		Q99638	Q9HAW4
PDB IDs		3A1J 3G65 3GGR 6HM5 6J8Y
Enriched GO Terms of Interacting Partners?
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