RAB5C and RIN2

Data Source:
HPRD (two hybrid)

		RAB5C	RIN2
Description		RAB5C, member RAS oncogene family	Ras and Rab interactor 2
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Lipid Droplet Plasma Membrane Endomembrane System Endocytic Vesicle Early Endosome Membrane Azurophil Granule Membrane Melanosome Extracellular Exosome	Cellular_component Cytosol
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity GTPase Regulator Activity
	Biological Process	Intracellular Protein Transport Endocytosis Regulation Of Endocytosis Neutrophil Degranulation Plasma Membrane To Endosome Transport	Endocytosis Small GTPase Mediated Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of GTPase Activity Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis
Pathways		Golgi Associated Vesicle Biogenesis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Macrocephaly, alopecia, cutis laxa, and scoliosis; MACS syndrome
GWAS		Coronary artery disease ( 29212778) Fibrinogen levels ( 28107422 26561523) Mean corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737) White blood cell count ( 32888494)	Bipolar disorder and schizophrenia ( 20889312) Bone mineral density (total hip) ( 29883787) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) HDL cholesterol ( 31170924) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Platelet distribution width ( 32888494 27863252) Response to valproic acid in genetic generalized epilepsy ( 32308125) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 32239398) Verbal declarative memory ( 25648963) Weight ( 28552196)
Interacting Genes		15 interacting genes: ALS2CL APP APPL2 EEA1 ERBB2 GLP1R HRAS INCA1 RABAC1 RBSN RIN2 RIN3 SGSM3 TBC1D15 TBC1D17	7 interacting genes: BIN1 CDKN2A EGFR ERBB2 RAB5A RAB5B RAB5C
Entrez ID		5878	54453
HPRD ID		04947	15249
Ensembl ID		ENSG00000108774	ENSG00000132669
Uniprot IDs		A0A024R1U4 P51148	A1A4T0 Q8WYP3
PDB IDs		4KYI
Enriched GO Terms of Interacting Partners?
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