RABIF and EIF3F

Data Source:
BioGRID (two hybrid)

		RABIF	EIF3F
Description		RAB interacting factor	eukaryotic translation initiation factor 3 subunit F
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GO Annotations	Cellular Component	Cytosol Membrane	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding	Translation Initiation Factor Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Metallopeptidase Activity Translation Initiation Factor Binding Identical Protein Binding Isopeptidase Activity Ubiquitinyl Hydrolase Activity
	Biological Process	Post-Golgi Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Protein Transport Regulation Of Catalytic Activity Membrane Fusion	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Protein Deubiquitination Protein Phosphopantetheinylation IRES-dependent Viral Translational Initiation
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs			Quercetin
Diseases
GWAS			Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depression (quantitative trait) ( 20800221) Malaria ( 31844061) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		29 interacting genes: EIF3F ITGA2 ITGA3 ITGA5 ITGA6 KIFC3 KYAT3 LAMTOR5 LARP1B LMCD1 LNX1 LRMDA LZTS1 RAB10 RAB15 RAB19 RAB1A RAB1B RAB3A RAB3B RAB3C RAB3D RAB8A RASSF5 REL TCF4 TERF2IP UTP14A ZNF544	44 interacting genes: AGR2 APP ATXN1 C1orf216 C6orf201 CCDC120 CCDC196 CDC42 CDK11A CDK11B CDK19 CDSN COL1A2 DKC1 EEF1A1 EIF3M EML2 ERCC6 FBXO32 HAX1 HGS HNRNPK HTR2A MCPH1 MKRN2 MSH4 MTOR MYDGF MYOZ1 NUP54 PBX4 PKN1 POGZ POU6F2 PTN RABIF RIN1 RPS6KB1 RTP5 SHBG SMAD9 SUOX TIMM10B WASHC1
Entrez ID		5877	8665
HPRD ID		04566	04887
Ensembl ID		ENSG00000183155	ENSG00000175390
Uniprot IDs		P47224 Q53EV1	O00303
PDB IDs		1FWQ 2FU5	3J8B 3J8C 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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