QDPR and PAH

Data Source:
BioGRID (two hybrid)

		QDPR	PAH
Description		quinoid dihydropteridine reductase	phenylalanine hydroxylase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Neuron Projection Extracellular Exosome	Cytosol
	Molecular Function	6,7-dihydropteridine Reductase Activity Electron Transfer Activity Identical Protein Binding NADPH Binding NADH Binding	Phenylalanine 4-monooxygenase Activity Iron Ion Binding
	Biological Process	Liver Development Cellular Amino Acid Metabolic Process L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Response To Aluminum Ion Response To Lead Ion Electron Transport Chain Response To Glucagon Cellular Response To Drug Dihydrobiopterin Metabolic Process	L-phenylalanine Catabolic Process Tyrosine Biosynthetic Process Cellular Amino Acid Biosynthetic Process Neurotransmitter Biosynthetic Process Catecholamine Biosynthetic Process
Pathways		Phenylalanine metabolism	Phenylketonuria Phenylalanine metabolism
Drugs		NADH 2-(N-morpholino)ethanesulfonic acid	Phenylalanine Sapropterin Norepinephrine Quinonoid 7,8-Tetrahydrobiopterin beta-2-Thienyl-L-alanine L-erythro-7,8-dihydrobiopterin D-norleucine Droxidopa
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient	Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Blood protein levels ( 30072576 29875488)	Amino acid levels ( 26068415) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood metabolite levels ( 24816252) Metabolite levels (small molecules and protein measures) ( 27005778) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		5 interacting genes: ANKRD13A CASP8 KRAS PAH RXFP4	3 interacting genes: PCBD1 QDPR RPS24
Entrez ID		5860	5053
HPRD ID		02025	08943
Ensembl ID		ENSG00000151552	ENSG00000171759
Uniprot IDs		A0A140VKA9 P09417	A0A024RBG4 P00439
PDB IDs		1HDR	1DMW 1J8T 1J8U 1KW0 1LRM 1MMK 1MMT 1PAH 1TDW 1TG2 2PAH 3PAH 4ANP 4PAH 5FII 5PAH 6HPO 6HYC 6N1K 6PAH
Enriched GO Terms of Interacting Partners?
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