EPS15L1 and SGIP1

Data Source:
BioGRID (pull down)

		EPS15L1	SGIP1
Description		epidermal growth factor receptor pathway substrate 15 like 1	SH3GL interacting endocytic adaptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Clathrin Coat Of Coated Pit	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit AP-2 Adaptor Complex Clathrin-coated Vesicle
	Molecular Function	Calcium Ion Binding Protein Binding Cadherin Binding	Protein Binding Phospholipid Binding Microtubule Binding SH3 Domain Binding
	Biological Process	Endocytosis Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization	Response To Dietary Excess Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Membrane Organization Clathrin-dependent Endocytosis Energy Homeostasis Positive Regulation Of Feeding Behavior
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Basophil count ( 32888494) Body size at age 10 ( 32376654) Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 29403010 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244 22190364 24076602) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) White blood cell count ( 32888494 27863252 21738480) White matter integrity ( 23218918)	Automobile speeding propensity ( 30643258) Cerebellum white matter volume ( 31530798) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronotype ( 30696823) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Menopause (age at onset) ( 23307926) Presence of antiphospholipid antibodies ( 23509613) Pulse pressure ( 30224653 30578418) Systolic blood pressure ( 30578418) TPE interval (resting) ( 32386560) Ulcerative colitis ( 28067908)
Interacting Genes		15 interacting genes: AGFG1 AGFG2 EPN1 FCHO1 FCHO2 GNG5 ITSN1 ITSN2 LRRC7 NDC80 SGIP1 STON2 TRAPPC2 TRAPPC2B UBC	5 interacting genes: APP DAB2 EPS15 EPS15L1 ITSN1
Entrez ID		58513	84251
HPRD ID		09445	10910
Ensembl ID		ENSG00000127527	ENSG00000118473
Uniprot IDs		A0A024R7G6 Q9UBC2	Q9BQI5
PDB IDs			5AWR 5AWS 5AWT 5AWU 6A9Y
Enriched GO Terms of Interacting Partners?
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