PYGB and PPP1R3B

Data Source:
BioGRID (two hybrid)

		PYGB	PPP1R3B
Description		glycogen phosphorylase B	protein phosphatase 1 regulatory subunit 3B
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Membrane Azurophil Granule Lumen Extracellular Exosome	Protein Phosphatase Type 1 Complex Glycogen Granule Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Glycogen Phosphorylase Activity Pyridoxal Phosphate Binding Linear Malto-oligosaccharide Phosphorylase Activity SHG Alpha-glucan Phosphorylase Activity	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity [phosphorylase] Phosphatase Activity Glycogen Binding
	Biological Process	Glycogen Catabolic Process Neutrophil Degranulation	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity
Pathways		Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs		Pyridoxal phosphate Alvocidib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Calcium levels ( 24068962) Diisocyanate-induced asthma ( 25918132) Liver enzyme levels (alkaline phosphatase) ( 22001757) Platelet distribution width ( 32888494) Serum alkaline phosphatase levels ( 31666285) Telomere length ( 30185882) TPE interval (resting) ( 32386560)	Acne (severe) ( 24927181) Alcohol use disorder (consumption score) ( 30940813) Aluminium levels ( 26025379) Alzheimer's disease ( 22832961) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 25961943 20686565) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Essential hypertension (time to event) ( 32589924) Estimated glomerular filtration rate ( 31015462) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood insulin ( 25631608 22581228) Fasting blood insulin (BMI interaction) ( 22581228) FEV1 ( 30804560) Fibrinogen levels ( 28107422) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Glycemic traits (pregnancy) ( 23903356) Glycine levels ( 31070104) HDL cholesterol ( 23726366 24097068 23505323 21347282 25961943 20686565) HDL cholesterol levels ( 28334899) Iron status biomarkers (total iron binding capacity) ( 28334935) Joint mobility (Beighton score) ( 27182965) LDL cholesterol ( 24097068 20864672 25961943 20686565) LDL cholesterol levels ( 28334899) Liver enzyme levels (alkaline phosphatase) ( 22001757) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Myopia (pathological) ( 23049088) Neuroticism ( 29255261) Nose size ( 27182965) Number of sexual partners ( 30643258) Peak expiratory flow ( 30804560) Plasma lactate levels ( 26433129) Refractive error ( 32231278) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Total cholesterol levels ( 28334899)
Interacting Genes		5 interacting genes: ACTN1 PPP1R3B PYGL PYGM SIAH1	7 interacting genes: IFNAR2 PLCE1 PPP1CA PPP1CB PPP1CC PYGB PYGM
Entrez ID		5834	79660
HPRD ID		00720	17894
Ensembl ID		ENSG00000100994	ENSG00000173281
Uniprot IDs		P11216	Q86XI6
PDB IDs		5IKO 5IKP	2EEF 5ZT0
Enriched GO Terms of Interacting Partners?
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