NFE4 and KMT2E

Data Source:
BioGRID (affinity chromatography technology)

		NFE4	KMT2E
Description		nuclear factor, erythroid 4	lysine methyltransferase 2E (inactive)
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Protein-containing Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Plasma Membrane Nuclear Body Nuclear Speck Protein-containing Complex Transcriptionally Active Chromatin
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Protein Binding Protein Homodimerization Activity DNA-binding Transcription Factor Binding	Protein Binding Histone-lysine N-methyltransferase Activity Enzyme Binding Methylated Histone Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly	Neutrophil Mediated Immunity DNA Methylation Cell Cycle Arrest Erythrocyte Differentiation Histone Lysine Methylation Neutrophil Activation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Histone H3-K4 Trimethylation
Pathways			PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)
Interacting Genes		3 interacting genes: HDAC1 KAT2B TFCP2	4 interacting genes: ASH2L ATP13A1 CDK1 LAMTOR5
Entrez ID		58160	55904
HPRD ID		19326	10528
Ensembl ID		ENSG00000230257	ENSG00000005483
Uniprot IDs		Q86UQ8	Q8IZD2
PDB IDs			2LV9 4L58 5HT6
Enriched GO Terms of Interacting Partners?
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